RPH3AL - rabphilin 3A like (without C2 domains) Gene

Homo sapiens

Also known as NOC2

Gene ID: 9501 | Gene type: protein coding

About RPH3AL

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:212,389-352,807 (from NCBI)

This gene has 22 transcripts (splice variants), 1 gene allele, 102 orthologues and 31 paralogues. Ubiquitous expression in spleen (RPKM 3.5), thyroid (RPKM 2.9) and 24 other tissues.

Summary

The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in Insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010]

RPH3AL Products(4)

mRNA	Protein	Name
NM_001190411.2	NP_001177340.1	rab effector Noc2 isoform 1
NM_001190412.2	NP_001177341.1	rab effector Noc2 isoform 2
NM_001190413.2	NP_001177342.1	rab effector Noc2 isoform 2
NM_006987.4	NP_008918.1	rab effector Noc2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPH3AL Protein Structure

FYVE_2

0
100
200
315 a.a.

Protein Preferred Names

Protein Names

rab effector Noc2

no C2 domains protein

RPH3AL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RPH3AL	Q9UNE2	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	25416956
Intra	RPH3AL	Q9UNE2	RAB27B	Homo sapiens	O00194	Y2H Prey Pooling	32296183
Intra	RPH3AL	Q9UNE2	PNMA3	Homo sapiens	Q9UL41	Y2H Prey Pooling	32296183
Intra	RPH3AL	Q9UNE2	PNMA3	Homo sapiens	Q9UL41	Y2H Array	32296183
Intra	RPH3AL	Q9UNE2	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	RPH3AL	Q9UNE2	PSME3	Homo sapiens	P61289	Y2H Array	32296183
Intra	RPH3AL	Q9UNE2	PSME3	Homo sapiens	P61289	Y2H Prey Pooling	32296183
Intra	RPH3AL	Q9UNE2	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	RPH3AL	Q9UNE2	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	RPH3AL	Q9UNE2	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	RPH3AL	Q9UNE2	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	RPH3AL	Q9UNE2	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Noonan Syndrome-Like Disorder With Loose Anagen Hair 2

NSLH2

Opportunistic Bacterial Infectious Disease

Nocardiosis

Nocardia Infection	Nocardia Infections
Nocardia Infectious Disease	Lung Nocardiosis
Nocardiasis	Nocardiosis Nos

Acute Contagious Conjunctivitis

Pink Eye	Contagious Opthalmia
Pinkeye	Conjunctivitis
Keratoconjunctivitis Due To Mycoplasma Conjunctivae

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12158	RPH3AL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RPH3AL	VGNC	VGNC:107275
Felis catus	RPH3AL	VGNC	VGNC:99435
Mus musculus	RPH3AL	MGD	MGI:1923492
Rattus norvegicus	RPH3AL	RGD	RGD:620342

Name
Email *

	Sorry, but the email address you supplied was invalid.