TNPO2 - transportin 2 Gene

Homo sapiens

Also known as IPO3; TRN2; KPNB2B; IDDHISD

Gene ID: 30000 | Gene type: protein coding

About TNPO2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,699,201-12,723,932 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 25.6), testis (RPKM 20.6) and 25 other tissues.

Summary

Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of muscle cell differentiation. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TNPO2 Products(11)

mRNA	Protein	Name
NM_001136195.2	NP_001129667.1	transportin-2 isoform 2
NM_001136196.2	NP_001129668.1	transportin-2 isoform 1
NM_001382236.1	NP_001369165.1	transportin-2 isoform 2
NM_001382237.1	NP_001369166.1	transportin-2 isoform 2
NM_001382238.1	NP_001369167.1	transportin-2 isoform 2
NM_001382239.1	NP_001369168.1	transportin-2 isoform 2
NM_001382240.1	NP_001369169.1	transportin-2 isoform 1
NM_001382241.1	NP_001369170.1	transportin-2 isoform 1
NM_001382242.1	NP_001369171.1	transportin-2 isoform 1
NM_001382243.1	NP_001369172.1	transportin-2 isoform 3
NM_013433.5	NP_038461.2	transportin-2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12896982	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNPO2 Protein Structure

IBN_N

HEAT_EZ

HEAT

0
200
400
600
800
897 a.a.

Protein Preferred Names

Protein Names

transportin-2

importin 3

TNPO2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNPO2	O14787	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	25416956
Intra	TNPO2	O14787	CAMK2D	Homo sapiens	Q13557	Y2H Prey Pooling	25416956
Intra	TNPO2	O14787	CAMK2D	Homo sapiens	Q13557	Y2H Array	31515488
Intra	TNPO2	O14787	APIP	Homo sapiens	Q96GX9	Y2H Array	25416956
Intra	TNPO2	O14787	APIP	Homo sapiens	Q96GX9	Y2H Array	31515488
Intra	TNPO2	O14787	APIP	Homo sapiens	Q96GX9	Validated Y2H	25416956
Intra	TNPO2	O14787	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	TNPO2	O14787	NME1	Homo sapiens	P15531	Validated Y2H	25416956
Intra	TNPO2	O14787	NME1	Homo sapiens	P15531	Y2H Prey Pooling	25416956
Intra	TNPO2	O14787	KLHL2	Homo sapiens	O95198	Y2H Array	31515488
Intra	TNPO2	O14787	KLHL2	Homo sapiens	O95198	Y2H Prey Pooling	25416956
Intra	TNPO2	O14787	KLHL2	Homo sapiens	O95198	Validated Y2H	25416956
Intra	TNPO2	O14787	KLHL2	Homo sapiens	O95198	Y2H Array	25416956
Intra	TNPO2	O14787	C1orf94	Homo sapiens	Q6P1W5	Y2H Prey Pooling	25416956
Intra	TNPO2	O14787	C1orf94	Homo sapiens	Q6P1W5	Y2H Array	25416956
Intra	TNPO2	O14787	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	25416956
Intra	TNPO2	O14787	EXOC5	Homo sapiens	O00471	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder With Hypotonia, Impaired Speech, And Dysmorphic Facies

IDDHISD

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14860	TNPO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TNPO2	VGNC	VGNC:79216
Canis familiaris	TNPO2	VGNC	VGNC:47695
Rattus norvegicus	TNPO2	RGD	RGD:1310356
Felis catus	TNPO2	VGNC	VGNC:66431
Mus musculus	TNPO2	MGD	MGI:2384849
Bos taurus	TNPO2	VGNC	VGNC:36200

Name
Email *

	Sorry, but the email address you supplied was invalid.