H1-3 - H1.3 linker histone, cluster member Gene

Homo sapiens

Also known as H1D; H1.3; H1F3; H1s-2; HIST1H1D

Gene ID: 3007 | Gene type: protein coding

About H1-3

Cytogenetic location: 6p22.2 Genomic coordinates (GRCh38): 6:26,234,212-26,234,987 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 9 paralogues.

Summary

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

H1-3 Products(1)

mRNA	Protein	Name
NM_005320.3	NP_005311.1	histone H1.3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	15911621	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	19882353	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	15911621	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H1-3 Protein Structure

Linker_histone

0
100
200
221 a.a.

Protein Preferred Names

Protein Names

histone H1.3

H1 histone family, member 3

H1-3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	H1-3	P16402	HMGA1	Homo sapiens	P17096	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Ophthalmomyiasis

Ocular Myiasis	Ophthalmic Myiasis
Myiasis Oestruosa

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-41404	Piperonylic acid	Inhibitor	99.91%	Unkown
HY-19120	KB-5492 anhydrous	Inhibitor	99.50%	Unkown
HY-47228	KB-5492 free base	Inhibitor	99.06%	Unkown
HY-137566	Cucumarioside H		/	Unkown
HY-162602	EGFR-IN-115	Inhibitor	/	Unkown
HY-RS05948	H1-3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W811579	Bensuldazic acid	Inhibitor	/	Unkown
HY-W811579A	Bensuldazic acid sodium	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	H1-3	VGNC	VGNC:109745
Mus musculus	H1-3	MGD	MGI:107502
Felis catus	H1-3	VGNC	VGNC:109856
Rattus norvegicus	H1-3	RGD	RGD:1585568

Name
Email *

	Sorry, but the email address you supplied was invalid.