HMGA1 - high mobility group AT-hook 1 Gene

Homo sapiens

Also known as HMG-R; HMGIY; HMGA1A

Gene ID: 3159 | Gene type: protein coding

About HMGA1

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:34,236,873-34,246,231 (from NCBI)

This gene has 9 transcripts (splice variants), 103 orthologues and is associated with 33 phenotypes. Broad expression in lymph node (RPKM 58.3), bone marrow (RPKM 57.3) and 23 other tissues.

Summary

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of Cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

HMGA1 Products(12)

mRNA	Protein	Name
NM_001319077.2	NP_001306006.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_001319078.2	NP_001306007.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319079.2	NP_001306008.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319080.2	NP_001306009.1	high mobility group protein HMG-I/HMG-Y isoform c
NM_001319081.2	NP_001306010.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_001319082.2	NP_001306011.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_002131.4	NP_002122.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145899.3	NP_665906.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_145901.3	NP_665908.1	high mobility group protein HMG-I/HMG-Y isoform a
NM_145902.3	NP_665909.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145903.3	NP_665910.1	high mobility group protein HMG-I/HMG-Y isoform b
NM_145905.3	NP_665912.1	high mobility group protein HMG-I/HMG-Y isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: Inferred from direct assay	19465398	GOA
enables DNA binding	EXP EXP: Inferred from Experiment	9253416	GOA
enables DNA binding	IDA IDA: Inferred from direct assay	11069991	GOA
enables DNA binding, bending	EXP EXP: Inferred from Experiment	22615915	GOA
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IDA IDA: Inferred from direct assay	19465398	GOA
enables RNA binding	IPI IPI: Inferred from physical interaction	21087998	GOA
enables cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9253416	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	16157300	GOA
enables minor groove of adenine-thymine-rich DNA binding	IDA IDA: Inferred from direct assay	9253416	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	11069991	GOA
enables molecular function activator activity	IMP IMP: Inferred from mutant phenotype	21087998	GOA
enables nuclear receptor coactivator activity	IMP IMP: Inferred from mutant phenotype	10428834	GOA
enables nuclear retinoic acid receptor binding	IDA IDA: Inferred from direct assay	10428834	GOA
enables nuclear retinoid X receptor binding	IDA IDA: Inferred from direct assay	10428834	GOA
enables peroxisome proliferator activated receptor binding	IDA IDA: Inferred from direct assay	10428834	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9809067	GOA
enables transcription coactivator activity	EXP EXP: Inferred from Experiment	9253416	GOA
enables transcription coactivator activity	IMP IMP: Inferred from mutant phenotype	10428834	GOA
enables transcription coregulator binding	IDA IDA: Inferred from direct assay	10428834	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in base-excision repair	IDA IDA: Inferred from direct assay	19465398	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	16901784	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16901784	GOA
involved in oncogene-induced cell senescence	IDA IDA: Inferred from direct assay	16901784	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	10428834	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16901784	GOA
located in senescence-associated heterochromatin focus	IDA IDA: Inferred from direct assay	16901784	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGA1 Protein Structure

AT_hook

0
100
107 a.a.

Protein Preferred Names

Protein Names

high mobility group protein HMG-I/HMG-Y

high mobility group protein A1

HMGA1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HMGA1	P17096	H1-3	Homo sapiens	P16402	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2BC21	Homo sapiens	Q16778	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	33961781
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	H2AC21	Homo sapiens	Q8IUE6	Crosslink	30021884
Intra	HMGA1	P17096	H4C16	Homo sapiens	P62805	Anti Tag CoIP	35271311
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	Pull Down	18234858
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	Anti Bait CoIP	18234858
Intra	HMGA1	P17096	ORC6	Homo sapiens	Q9Y5N6	BiFC	18234858

Cross: Cross-species interaction Intra: Intraspecies interaction

HMGA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81440	HMGA1 Antibody (YA1185)	IHC-P	Human

Related Diseases

Diseases

Alias

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Lipomatosis, Multiple

Lipoma	Familial Multiple Lipomatosis
Lipomatosis, Familial Multiple	Benign Lipomatous Tumor
Lipomatous Neoplasm	Multiple Lipomatosis
Fml	Lipo
Benign Tumor Of Adipose Tissue	Lipomatous Tumor
Tumor Of Adipose Tissue	Neoplasms, Adipose Tissue
Lipomas

Pelvic Lipomatosis

Excess Of Mature Unencapsulated Fatty Tissue In The Pelvis

Adenoma

Acinar Cell Adenoma	Adenomas
Acinic Cell Adenoma

Leiomyoma, Uterine

Uterine Leiomyoma	Uterine Fibroid
Uterine Fibroids	Plexiform Leiomyoma
UL	Leiomyoma Of Corpus Uteri
Uterus Fibroma

Breast Fibroadenoma

Fibroadenoma	Fibroadenoma Of Breast
Juvenile Fibroadenoma Of Breast	Cellular Fibroadenoma
Complex Fibroadenoma Of Breast	Juvenile Fibroadenoma
Fibroadenoma Nos	Fibroadenoma Unspecified Site

Dermatofibrosarcoma Protuberans

DFSP	Dermatofibrosarcoma
Giant Cell Fibroblastoma	Metastatic Dermatofibrosarcoma Protuberans
Familial Dermatofibrosarcoma Protuberans	Darier-Ferrand Tumor
Darier-Hoffmann Tumor

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06230	HMGA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HMGA1	RGD	RGD:628699
Bos taurus	HMGA1	VGNC	VGNC:29874
Mus musculus	HMGA1	MGD	MGI:96160
Canis familiaris	HMGA1	VGNC	VGNC:41709
Macaca mulatta	HMGA1	VGNC	VGNC:81076

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