2. Gene
  3. F8 - coagulation factor VIII Gene

F8 - coagulation factor VIII Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 302470 | Gene type: protein coding

About F8

Summary

Predicted to enable copper ion binding activity and oxidoreductase activity. Involved in blood coagulation, intrinsic pathway. Located in extracellular space. Used to study Factor VIII deficiency; hemarthrosis; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in Factor VIII deficiency. Orthologous to human F8 (coagulation Factor VIII). [provided by Alliance of Genome Resources, Apr 2022]

F8 Products(1)

mRNA Protein Name
NM_183331.2 NP_899160.2 coagulation factor VIII precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in blood coagulation, intrinsic pathway IMP
IMP: Inferred from mutant phenotype
2513867 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
2513867 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

coagulation factor VIII

coagulation factor VIII, procoagulant component

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-107530 3F8 Inhibitor / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99757 Nivatrotamab Inhibitor 99.40% Phase 2
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D2377 F8 98.25% Unkown
HY-157252 CL4F8-6 99.80% Unkown
HY-147844 F8-S43-S3 Inhibitor / Unkown
HY-147845 F8-S40 Inhibitor / Unkown
HY-157125 PI3Kα-IN-14 / Unkown
HY-RS04117 E2F8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04646 F8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04647 F8A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-171036 GAPDH-IN-1 Inhibitor / Unkown
HY-W391641 F8BT / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990214 Anti-Mouse IL-3 Antibody (MP2-8F8) Inhibitor 95.00% Unkown
HY-P990221 Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens F8 NCBI NCBI:2157
Felis catus F8 NCBI NCBI:101092751
Macaca fascicularis F8 NCBI NCBI:102125498
Mus musculus F8 NCBI NCBI:14069