2. Gene
  3. Mpo - myeloperoxidase Gene

Mpo - myeloperoxidase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 303413 | Gene type: protein coding

About Mpo

Summary

Enables peroxidase activity. Involved in several processes, including response to food; response to gold nanoparticle; and response to lipopolysaccharide. Located in extracellular space. Used to study acute kidney failure. Biomarker of chronic obstructive pulmonary disease; cystitis; and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase). [provided by Alliance of Genome Resources, Apr 2022]

Mpo Products(2)

mRNA Protein Name
NM_001401812.1 NP_001388741.1 myeloperoxidase precursor
NM_001401812.1 NP_001388741.1 myeloperoxidase precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peroxidase activity IDA
IDA: Inferred from direct assay
12922978 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to food IEP
IEP: Inferred from expression pattern
15788232 RGD
involved in response to gold nanoparticle IEP
IEP: Inferred from expression pattern
23150627 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15788232 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
9518261 RGD
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
12922978 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
7996547 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myeloperoxidase

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0679 Lubiprostone ≥98.0% Yes
Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-145581 Mitiperstat Inhibitor 99.12% Phase 3
HY-17646 Verdiperstat Inhibitor 99.85% Phase 3
HY-106228 HLF1-11 Inhibitor 99.91% Phase 2
HY-105017 Evodenoson Agonist 99.74% Phase 2
HY-111341 AZD5904 Inhibitor 99.93% Phase 1
Pre-clinical Phase
Bioactive Molecules (24)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100873 PF-1355 Inhibitor 99.80% Unkown
HY-B0880 4-Aminobenzohydrazide Inhibitor 99.96% Unkown
HY-115486 MPO-IN-28 Inhibitor 99.28% Unkown
HY-N6937 (R,R)-Secoisolariciresinol diglucoside 99.84% Unkown
HY-125039 N-Acetyl lysyltyrosylcysteine amide Inhibitor 99.81% Unkown
HY-125859A Myeloperoxidase, human white blood cells Inhibitor / Unkown
HY-145197 MPO-IN-3 Inhibitor 99.73% Unkown
HY-139915 MPO-IN-1 Inhibitor 99.02% Unkown
HY-N11552 Sorbifolin Inhibitor 99.58% Unkown
HY-115828 APA-APA-MPO dihydrochloride / Unkown
HY-115829 APA-H-MPO hydrochloride / Unkown
HY-116188 HX1 / Unkown
HY-146651 MPO-IN-4 Inhibitor / Unkown
HY-147691 MPO-IN-5 Inhibitor / Unkown
HY-147692 COX-2-IN-14 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-163335 MPO-IN-7 Inhibitor / Unkown
HY-168002 MPO-IN-8 / Unkown
HY-N10439 3β-Acetoxy-hop-22(29)-ene Inhibitor / Unkown
HY-N6937S1 (R,R)-Secoisolariciresinol diglucoside-d6 / Unkown
HY-P10868 Pegtarazimod Inducer / Unkown
HY-RS08621 MPO Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-103388 NCX 466 Inhibitor / Unkown
HY-132132 Neutrophil elastase inhibitor 3 Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990812 Anti-Mouse myeloperoxidase/MPO Antibody (6D1) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpo NCBI NCBI:4353
Macaca fascicularis Mpo NCBI NCBI:102130410
Mus musculus Mpo NCBI NCBI:17523
Macaca mulatta Mpo NCBI NCBI:714246