2. Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. Fungal Bacterial Glutathione Peroxidase
  4. HLF1-11

HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses.

For research use only. We do not sell to patients.

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HLF1-11 Chemical Structure

HLF1-11 Chemical Structure

CAS No. : 183623-03-2

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Based on 1 publication(s) in Google Scholar

HLF1-11 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

HLF1-11, a human lactoferrin-derived peptide, is a broad spectrum antimicrobial agent. HLF1-11 inhibits human MPO activity. HLF1-11 also directs GM-CSF-driven monocyte differentiation toward macrophages, and enhances immune responses[1][2].

In Vitro

hLF1-11 (1, 10, and 100 μg/mL) directs differentiation of monocytes toward a macrophage subset during granulocyte-macrophage colony-stimulating factor (GM-CSF)-driven monocytes differentiation[2].
hLF1-11 (0.5-250 μg/mL) inhibits human MPO activity[3].
hLF1-11 (100 μg/mL, 90 min) inhibits ROS induction induced by LPS in monocytes[3].
hLF1-11 (8-34 μΜ, 2 h) is active against fluconazole-resistant C. albicans[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HLF1-11 Related Antibodies
In Vivo

hLF1-11 (20 mg/kg, injected into the debrided tibial cavity) shows ability against MRSA osteomyelitis in rabbits[4].
hLF1-11 (40 μg/kg, i.v.) is active against C. albicans-infected mice[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbits inoculated with CFU MRSA[4]
Dosage: 20 mg/kg
Administration: Injected into the debrided tibial cavity
Result: Reduced bacterial load compared to controls, and reduced the radiological and histopathological score.
Animal Model: Neutropenic mice challenged i.v. with C. albicans
Dosage: 40 μg/kg
Administration: Intravenous injection (i.v)
Result: Reduced serum TNFα and IL-6 in infected mice.
Clinical Trial
Molecular Weight

1374.58

Formula

C56H95N25O14S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

GRRRRSVQWCA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (72.75 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 100 mg/mL (72.75 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7275 mL 3.6375 mL 7.2750 mL
5 mM 0.1455 mL 0.7275 mL 1.4550 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

SDS (252 KB)

COA (250 KB) LCMS (89 KB) Elemental Analysis Report (109 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 0.7275 mL 3.6375 mL 7.2749 mL 18.1874 mL
5 mM 0.1455 mL 0.7275 mL 1.4550 mL 3.6375 mL
10 mM 0.0727 mL 0.3637 mL 0.7275 mL 1.8187 mL
15 mM 0.0485 mL 0.2425 mL 0.4850 mL 1.2125 mL
20 mM 0.0364 mL 0.1819 mL 0.3637 mL 0.9094 mL
25 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
30 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.6062 mL
40 mM 0.0182 mL 0.0909 mL 0.1819 mL 0.4547 mL
50 mM 0.0145 mL 0.0727 mL 0.1455 mL 0.3637 mL
60 mM 0.0121 mL 0.0606 mL 0.1212 mL 0.3031 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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HLF1-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HLF1-11183623-03-2FungalBacterialGlutathione PeroxidaseInfectionantimicrobialmonocytesmonocytes differentiationC. albicansInhibitorinhibitorinhibit

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