2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase
  4. MPO-IN-3

MPO-IN-3 is a potent myeloperoxidase (MPO) inhibitor (WO2013068875A1, example 191). Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the peroxidase superfamily.

For research use only. We do not sell to patients.

MPO-IN-3 Chemical Structure

MPO-IN-3 Chemical Structure

CAS No. : 1435469-45-6

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Based on 1 publication(s) in Google Scholar

MPO-IN-3 Related Antibodies

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Description

MPO-IN-3 is a potent myeloperoxidase (MPO) inhibitor (WO2013068875A1, example 191). Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the peroxidase superfamily[1].

Molecular Weight

371.88

Formula

C16H22ClN3O3S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(N(CCCCN)C(N1)=S)C2=C(OC)C=C(OC)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (268.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6890 mL 13.4452 mL 26.8904 mL
5 mM 0.5378 mL 2.6890 mL 5.3781 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6890 mL 13.4452 mL 26.8904 mL 67.2260 mL
5 mM 0.5378 mL 2.6890 mL 5.3781 mL 13.4452 mL
10 mM 0.2689 mL 1.3445 mL 2.6890 mL 6.7226 mL
15 mM 0.1793 mL 0.8963 mL 1.7927 mL 4.4817 mL
20 mM 0.1345 mL 0.6723 mL 1.3445 mL 3.3613 mL
25 mM 0.1076 mL 0.5378 mL 1.0756 mL 2.6890 mL
30 mM 0.0896 mL 0.4482 mL 0.8963 mL 2.2409 mL
40 mM 0.0672 mL 0.3361 mL 0.6723 mL 1.6806 mL
50 mM 0.0538 mL 0.2689 mL 0.5378 mL 1.3445 mL
60 mM 0.0448 mL 0.2241 mL 0.4482 mL 1.1204 mL
80 mM 0.0336 mL 0.1681 mL 0.3361 mL 0.8403 mL
100 mM 0.0269 mL 0.1345 mL 0.2689 mL 0.6723 mL
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MPO-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MPO-IN-31435469-45-6Glutathione PeroxidasemyeloperoxidaseperoxidasecardiovascularInhibitorinhibitorinhibit

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