Sirt7 - sirtuin 7 Gene

Rattus norvegicus

Gene ID: 303745 | Gene type: protein coding

About Sirt7

Primary_assembly 10: 105,896,476-105,903,172 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 189 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in Thymus (RPKM 16.5), Spleen (RPKM 93.4) and 9 other tissues.

Summary

Predicted to enable several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; protein-propionyllysine depropionylase activity; and transcription corepressor activity. Predicted to be involved in several processes, including cellular macromolecule biosynthetic process; protein deacylation; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nuclear speck; nucleolus organizer region; and site of double-strand break. Predicted to be active in nucleus. Orthologous to human SIRT7 (Sirtuin 7). [provided by Alliance of Genome Resources, Apr 2022]

Sirt7 Products(1)

mRNA	Protein	Name
NM_001107073.1	NP_001100543.1	NAD-dependent protein deacetylase sirtuin-7

Sirt7 Protein Structure

Smc

SIRT7

0
100
200
300
400
426 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacetylase sirtuin-7

NAD-dependent deacetylase sirtuin-7	NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7	regulatory protein SIR2 homolog 7

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135899	SIRT7 inhibitor 97491	Inhibitor	98.03%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-159124	YZL-51N	Inhibitor	/	Unkown
HY-156489	Epigenetic factor-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sirt7	NCBI	NCBI:51547

Name
Email *

	Sorry, but the email address you supplied was invalid.