SIRT7 - sirtuin 7 Gene

Homo sapiens

Also known as SIR2L7

Gene ID: 51547 | Gene type: protein coding

About SIRT7

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,911,939-81,918,176 (from NCBI)

This gene has 21 transcripts (splice variants), 189 orthologues and 6 paralogues. Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the Sirtuin family. [provided by RefSeq, Jul 2008]

SIRT7 Products(6)

mRNA	Protein	Name
XM_011523580.2	XP_011521882.1	NAD-dependent protein deacetylase sirtuin-7 isoform X1
XM_047436231.1	XP_047292187.1	NAD-dependent protein deacetylase sirtuin-7 isoform X5
XM_047436229.1	XP_047292185.1	NAD-dependent protein deacetylase sirtuin-7 isoform X3
XM_047436228.1	XP_047292184.1	NAD-dependent protein deacetylase sirtuin-7 isoform X2
XM_047436230.1	XP_047292186.1	NAD-dependent protein deacetylase sirtuin-7 isoform X4
NM_016538.3	NP_057622.1	NAD-dependent protein deacetylase sirtuin-7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD-dependent histone H3K18 deacetylase activity	IDA IDA: Inferred from direct assay	22722849	GOA
enables NAD-dependent histone H3K18 deacetylase activity	IMP IMP: Inferred from mutant phenotype	28655758	GOA
enables NAD-dependent protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	24207024	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	22722849	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19174463	GOA
enables protein methyltransferase activity	IDA IDA: Inferred from direct assay	24207024	GOA
enables protein-glutaryllysine deglutarylase activity	IDA IDA: Inferred from direct assay	31542297	GOA
enables protein-succinyllysine desuccinylase activity	IDA IDA: Inferred from direct assay	27436229	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	30944854	GOA
involved in DNA repair-dependent chromatin remodeling	IDA IDA: Inferred from direct assay	27436229	GOA
involved in R-loop processing	IDA IDA: Inferred from direct assay	28790157	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	28147277	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	28886238	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22722849	GOA
involved in positive regulation of gluconeogenesis	IMP IMP: Inferred from mutant phenotype	28655758	GOA
involved in positive regulation of rRNA processing	IDA IDA: Inferred from direct assay	26867678	GOA
involved in positive regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	30540930	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	24207024	GOA
involved in protein deglutarylation	IDA IDA: Inferred from direct assay	31542297	GOA
involved in rRNA transcription	IMP IMP: Inferred from mutant phenotype	19174463	GOA
involved in regulation of DNA repair	IDA IDA: Inferred from direct assay	30944854	GOA
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	30420520	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	28426094	GOA
involved in regulation of transcription of nucleolar large rRNA by RNA polymerase I	IDA IDA: Inferred from direct assay	24207024	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	28655758	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	30944854	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	16079181	GOA
located in nucleolus organizer region	IDA IDA: Inferred from direct assay	19174463	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	24207024	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	36646384	GOA
located in nucleus	IDA IDA: Inferred from direct assay	31075303	GOA
located in site of double-strand break	IDA IDA: Inferred from direct assay	27436229	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIRT7 Protein Structure

SIR2

0
100
200
300
400 a.a.

Protein Preferred Names

Protein Names

NAD-dependent protein deacetylase sirtuin-7

NAD-dependent deacetylase sirtuin-7	NAD-dependent protein deacylase sirtuin-7
SIR2-like protein 7	regulatory protein SIR2 homolog 7
silent mating type information regulation 2, S.cerevisiae, homolog 7	sir2-related protein type 7
sirtuin type 7

SIRT7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIRT7	Q9NRC8	ELK4	Homo sapiens	P28324	Anti Bait CoIP	22722849
Intra	SIRT7	Q9NRC8	ELK4	Homo sapiens	P28324	Anti Tag CoIP	22722849
Intra	SIRT7	Q9NRC8	NRF1	Homo sapiens	Q16656	Anti Bait CoIP	25792330
Intra	SIRT7	Q9NRC8	NRF1	Homo sapiens	Q16656	Anti Tag CoIP	25792330

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135899	SIRT7 inhibitor 97491	Inhibitor	98.03%	Unkown
HY-150727	SIRT5 inhibitor 4	Inhibitor	/	Unkown
HY-159124	YZL-51N	Inhibitor	/	Unkown
HY-156489	Epigenetic factor-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SIRT7	VGNC	VGNC:65161
Canis familiaris	SIRT7	VGNC	VGNC:46188
Macaca mulatta	SIRT7	VGNC	VGNC:77487
Mus musculus	SIRT7	MGD	MGI:2385849
Bos taurus	SIRT7	VGNC	VGNC:34636
Rattus norvegicus	SIRT7	RGD	RGD:1305876

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