HAS3 - hyaluronan synthase 3 Gene

Homo sapiens

Gene ID: 3038 | Gene type: protein coding

About HAS3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,083,484-69,118,719 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in urinary bladder (RPKM 19.2), lung (RPKM 12.8) and 24 other tissues.

Summary

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by Other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

HAS3 Products(3)

mRNA	Protein	Name
NM_001199280.2	NP_001186209.1	hyaluronan synthase 3 isoform a
NM_005329.3	NP_005320.2	hyaluronan synthase 3 isoform a
NM_138612.3	NP_619515.1	hyaluronan synthase 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hyaluronan synthase activity	IDA IDA: Inferred from direct assay	16900089	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25795779	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20507985	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in hyaluronan biosynthetic process	IDA IDA: Inferred from direct assay	16900089	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16900089	GOA
involved in positive regulation of hyaluranon cable assembly	IDA IDA: Inferred from direct assay	16900089	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25795779	GOA
located in hyaluranon cable	IDA IDA: Inferred from direct assay	16900089	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25795779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAS3 Protein Structure

Glyco_tranf_2_3

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

hyaluronan synthase 3

HA synthase 3

HAS3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAS3	O00219	HAS1	Homo sapiens	Q92839	FRET	25795779
Intra	HAS3	O00219	HAS1	Homo sapiens	Q92839	Anti Tag CoIP	25795779
Intra	HAS3	O00219	HAS2	Homo sapiens	Q92819	FRET	25795779
Intra	HAS3	O00219	HAS3	Homo sapiens	O00219	Anti Tag CoIP	25795779
Intra	HAS3	O00219	HAS3	Homo sapiens	O00219	Confocal	25795779
Intra	HAS3	O00219	HAS3	Homo sapiens	O00219	FRET	25795779

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-143894	FLT3-IN-11	Inhibitor	/	Unkown
HY-RS06008	HAS3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HAS3	RGD	RGD:628656
Canis familiaris	HAS3	VGNC	VGNC:41601
Mus musculus	HAS3	MGD	MGI:109599
Macaca mulatta	HAS3	VGNC	VGNC:73348
Felis catus	HAS3	VGNC	VGNC:67537
Bos taurus	HAS3	VGNC	VGNC:29756

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