Gdf1 - growth differentiation factor 1 Gene

Rattus norvegicus

Gene ID: 306351 | Gene type: protein coding

About Gdf1

Summary

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta Superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. The mouse ortholog of this gene is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the LAG1 homolog, ceramide synthase 1 gene. Mono-cistronic transcripts for this gene are also found in mouse, but it is not known if they exist in rat. [provided by RefSeq, Jul 2009]

Gdf1 Products(1)

mRNA	Protein	Name
NM_001044240.2	NP_001037705.1	embryonic growth/differentiation factor 1 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	24275554	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

embryonic growth/differentiation factor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05349	GDF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gdf1	NCBI	NCBI:2657
Canis familiaris	Gdf1	NCBI	NCBI:100686938
Macaca fascicularis	Gdf1	NCBI	NCBI:102130721
Mus musculus	Gdf1	NCBI	NCBI:14559

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