HDLBP - high density lipoprotein binding protein Gene

Homo sapiens

Also known as HBP; VGL; PRO2900

Gene ID: 3069 | Gene type: protein coding

About HDLBP

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:241,227,291-241,315,672 (from NCBI)

This gene has 47 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 89.6), thyroid (RPKM 63.1) and 25 other tissues.

Summary

The protein encoded by this gene binds high density lipoprotein (HDL) and may function to regulate excess Cholesterol levels in cells. The encoded protein also binds RNA and can induce heterochromatin formation. [provided by RefSeq, Mar 2016]

HDLBP Products(6)

mRNA	Protein	Name
NM_001243900.3	NP_001230829.1	vigilin isoform b
NM_001320965.3	NP_001307894.1	vigilin isoform a
NM_001320966.3	NP_001307895.1	vigilin isoform a
NM_001320967.3	NP_001307896.1	vigilin isoform c
NM_005336.6	NP_005327.1	vigilin isoform a
NM_203346.6	NP_976221.1	vigilin isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24725430	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDLBP Protein Structure

KH_1

0
200
400
600
800
1000
1200
1268 a.a.

Protein Preferred Names

Protein Names

vigilin

HDL-binding protein

HDLBP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HDLBP	Q00341	RAD51	Homo sapiens	Q06609	Anti Bait CoIP	33941620
Intra	HDLBP	Q00341	CTCF	Homo sapiens	P49711	Anti Bait CoIP	24725430

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome	2q37 Microdeletion Syndrome
Brachydactyly-Intellectual Disability Syndrome	Deletion 2q37
2q37 Deletion Syndrome	Brachydactyly-Mental Retardation Syndrome
Bdmr	Albright Hereditary Osteodystrophy Type 3
Del(2)(Q37)	Monosomy 2q37qter
Albright'S Hereditary Osteodystrophy-Like Syndrome	Monosomy 2q37
Chromosome Deletion Syndrome 2q37

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06099	HDLBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HDLBP	VGNC	VGNC:73361
Rattus norvegicus	HDLBP	RGD	RGD:620962
Bos taurus	HDLBP	VGNC	VGNC:55051
Mus musculus	HDLBP	MGD	MGI:99256
Felis catus	HDLBP	VGNC	VGNC:67551
Canis familiaris	HDLBP	VGNC	VGNC:41631

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