2. Gene
  3. KCNIP1 - potassium voltage-gated channel interacting protein 1 Gene

KCNIP1 - potassium voltage-gated channel interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VABP; KCHIP1

Gene ID: 30820 | Gene type: protein coding

About KCNIP1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:170,353,487-170,736,632 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 14 paralogues. Biased expression in brain (RPKM 5.5), testis (RPKM 1.0) and 6 other tissues.

Summary

This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

KCNIP1 Products(5)

mRNA Protein Name
NM_001034837.3 NP_001030009.1 Kv channel-interacting protein 1 isoform 1
NM_001034838.3 NP_001030010.1 Kv channel-interacting protein 1 isoform 3
NM_001278339.2 NP_001265268.1 Kv channel-interacting protein 1 isoform 5
NM_001278340.2 NP_001265269.1 Kv channel-interacting protein 1 isoform 4
NM_014592.4 NP_055407.1 Kv channel-interacting protein 1 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
17187064 GOA
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
10676964 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10551270 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
10676964 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Kv4.3-KChIP1 channel complex IPI
IPI: Inferred from physical interaction
17187064 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10676964 GOA
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
10676964 GOA
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
10676964 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNIP1 Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (77 - 126)

EF-hand_7

EF-hand_7: EF-hand domain pair (137 - 208)

  • 0
  • 100
  • 200
  • 227 a.a.
Protein Preferred Names Protein Names

Kv channel-interacting protein 1

A-type potassium channel modulatory protein 1

KCNIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
KCNIP1 Q9NZI2 KCNIP2 Homo sapiens Q9NS61-3
Pull Down
15358149
Intra
KCNIP1 Q9NZI2 KCND2 Homo sapiens Q9NZV8
Pull Down
15358149
Intra
KCNIP1 Q9NZI2 KCND3 Homo sapiens Q9UK17
X-Ray Diffraction
17187064
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy

Generalised Epilepsy

Epilepsy, Generalized

EIG

Ige

Epilepsy, Idiopathic Generalized, Susceptibility To, 1

Epilepsy, Idiopathic Generalized 1

Epilepsy, Idiopathic Generalized, Susceptibility To

Epilepsy, Idiopathic, Generalized

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Hypertension, Diastolic

Hypertension, Diastolic, Resistance To

Diastolic Hypertension
Bacterial Pneumonia

Gram-Negative Pneumonia

Pneumonia Due To Other Gram-Negative Bacteria

Pneumonia Bacterial

Pneumonia, Bacterial

Acute Bacillus Pneumonia

Acute Bacterial Pneumonia

Bacillus Double Pneumonia

Bacillus Pneumonia

Bacteria Pneumonia

Bacterial Double Pneumonia

Bacterial Lobar Pneumonia

Bacterial Purulent Pneumonia

Bronchopneumonia Due To Bacteria Other Than S. Pneumoniae And H. Influenzae
Acute Pyelonephritis

Apn - [Acute Pyelonephritis]
Pyelitis
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
Urinary Tract Infection

Urinary Tract Infections

Uti

Urinary Tract Infection Nos

Uti - [Urinary Tract Infection]

Uti Nos - [Urinary Tract Infection Nos]

Urosepsis Nos

E Coli Uti

E Coli Urinary Tract Infection

Escherichia Coli Uti
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07132 KCNIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus KCNIP1 MGD MGI:1917607
Canis familiaris KCNIP1 VGNC VGNC:42254
Felis catus KCNIP1 VGNC VGNC:63040
Rattus norvegicus KCNIP1 RGD RGD:70886
Macaca mulatta KCNIP1 VGNC VGNC:73832
Bos taurus KCNIP1 VGNC VGNC:30450