STOML2 - stomatin like 2 Gene

Homo sapiens

Also known as SLP-2; HSPC108

Gene ID: 30968 | Gene type: protein coding

About STOML2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,099,776-35,103,195 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 27.8), heart (RPKM 26.8) and 25 other tissues.

Summary

Enables GTPase binding activity and cardiolipin binding activity. Involved in several processes, including inorganic cation transmembrane transport; positive regulation of cardiolipin metabolic process; and positive regulation of mitochondrial DNA replication. Located in membrane raft; mitochondrial inner membrane; and mitochondrial intermembrane space. Is extrinsic component of plasma membrane. Colocalizes with several cellular components, including COP9 signalosome; T cell receptor complex; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

STOML2 Products(4)

mRNA	Protein	Name
NM_001287031.2	NP_001273960.1	stomatin-like protein 2, mitochondrial isoform b
NM_001287032.1	NP_001273961.1	stomatin-like protein 2, mitochondrial isoform c
NM_001287033.2	NP_001273962.1	stomatin-like protein 2, mitochondrial isoform d
NM_013442.3	NP_038470.1	stomatin-like protein 2, mitochondrial isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase binding	IPI IPI: Inferred from physical interaction	24337748	GOA
enables T cell receptor binding	IDA IDA: Inferred from direct assay	18641330	GOA
enables cardiolipin binding	IDA IDA: Inferred from direct assay	21746876	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17121834	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18641330	GOA
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	19944461	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	21746876	GOA
involved in protein complex oligomerization	IDA IDA: Inferred from direct assay	17121834	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	18641330	GOA
located in immunological synapse	IDA IDA: Inferred from direct assay	22623988	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	18641330	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	17121834	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	17121834	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22623988	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STOML2 Protein Structure

Band_7

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

stomatin-like protein 2, mitochondrial

EPB72-like 2

STOML2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STOML2	Q9UJZ1	ATXN2	Homo sapiens	Q99700-5	Validated Y2H	32814053
Intra	STOML2	Q9UJZ1	ATXN2	Homo sapiens	Q99700-5	Y2H Array	32814053
Intra	STOML2	Q9UJZ1	ATXN2	Homo sapiens	Q99700-5	Y2H Pooling	32814053
Intra	STOML2	Q9UJZ1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	STOML2	Q9UJZ1	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	STOML2	Q9UJZ1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	STOML2	Q9UJZ1	PEX1	Homo sapiens	O43933	Validated Y2H	32814053
Intra	STOML2	Q9UJZ1	PEX1	Homo sapiens	O43933	Y2H Array	32814053
Intra	STOML2	Q9UJZ1	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

STOML2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81975	SLP2 Antibody (YA1720)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Macroglobulinemia

Primary Macroglobulinemia

Waldenstrom Macroglobulinemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122671	OB-1	Inhibitor	99.12%	Unkown
HY-122671S	OB-1-d3	Control	/	Unkown
HY-RS13950	STOML2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	STOML2	VGNC	VGNC:35411
Rattus norvegicus	STOML2	RGD	RGD:1308285
Macaca mulatta	STOML2	VGNC	VGNC:78116
Mus musculus	STOML2	MGD	MGI:1913842
Felis catus	STOML2	VGNC	VGNC:65794

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