HIVEP2 - HIVEP zinc finger 2 Gene

Homo sapiens

Also known as SHN2; ZAS2; MBP-2; MIBP1; MRD43; ZNF40B; HIV-EP2

Gene ID: 3097 | Gene type: protein coding

About HIVEP2

Cytogenetic location: 6q24.2 Genomic coordinates (GRCh38): 6:142,751,469-142,946,365 (from NCBI)

This gene has 10 transcripts (splice variants), 272 orthologues, 14 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 14.4), ovary (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a member of a family of closely related, large, zinc finger-containing transcription factors. The encoded protein regulates transcription by binding to regulatory regions of various cellular and viral genes that maybe involved in growth, development and metastasis. The protein contains the ZAS domain comprised of two widely separated regions of zinc finger motifs, a stretch of highly acidic Amino acids and a serine/threonine-rich sequence. [provided by RefSeq, Nov 2012]

HIVEP2 Products(1)

mRNA	Protein	Name
NM_006734.4	NP_006725.3	transcription factor HIVEP2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20936779	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIVEP2 Protein Structure

zf-H2C2_2

0
400
800
1200
1600
2000
2446 a.a.

Protein Preferred Names

Protein Names

transcription factor HIVEP2

MHC binding protein-2

HIVEP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HIVEP2	P31629	YWHAG	Homo sapiens	P61981	Y2H Pooling	20936779

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, Autosomal Dominant 43

MRD43	Autosomal Dominant Non-Syndromic Intellectual Disability 43
Autosomal Dominant Intellectual Developmental Disorder 43	Autosomal Dominant Mental Retardation 43

Hivep2-Related Intellectual Disability

Mental Retardation, Autosomal Dominant 43	Intellectual Disability, Autosomal Dominant 43
Autosomal Dominant Intellectual Disability-43	Mrd43

Autosomal Dominant Non-Syndromic Intellectual Disability

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Schizophrenia 12

Sczd12

Schizophrenia Susceptibility Locus, Chromosome 1p-Related

Macular Dystrophy, Patterned, 2

Patterned Macular Dystrophy 2	MDPT2
Macular Dystrophy, Butterfly-Shaped Pigmentary, 2	Butterfly-Shaped Pigmentary Maculary Dystrophy 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06188	HIVEP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HIVEP2	VGNC	VGNC:96548
Macaca mulatta	HIVEP2	VGNC	VGNC:83427
Rattus norvegicus	HIVEP2	RGD	RGD:61988
Bos taurus	HIVEP2	VGNC	VGNC:96543
Canis familiaris	HIVEP2	VGNC	VGNC:81688
Mus musculus	HIVEP2	MGD	MGI:1338076

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