HK3 - hexokinase 3 Gene

Homo sapiens

Also known as HXK3; HKIII

Gene ID: 3101 | Gene type: protein coding

About HK3

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,880,869-176,899,346 (from NCBI)

This gene has 6 transcripts (splice variants), 129 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 50.3), spleen (RPKM 14.0) and 3 other tissues.

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes Hexokinase 3. Similar to hexokinases 1 and 2, this allosteric Enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

HK3 Products(1)

mRNA	Protein	Name
NM_002115.3	NP_002106.2	hexokinase-3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables hexokinase activity	IDA IDA: Inferred from direct assay	8717435	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HK3 Protein Structure

Hexokinase_1

Hexokinase_2

Hexokinase_1

Hexokinase_2

0
200
400
600
800
923 a.a.

Protein Preferred Names

Protein Names

hexokinase-3

ATP:D-hexose 6-phosphotransferase

HK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HK3	P52790	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	HK3	P52790	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	HK3	P52790	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	HK3	P52790	ATN1	Homo sapiens	Q86V38	Validated Y2H	32814053
Intra	HK3	P52790	ATN1	Homo sapiens	Q86V38	Y2H Pooling	32814053
Intra	HK3	P52790	ATN1	Homo sapiens	Q86V38	Y2H Array	32814053
Intra	HK3	P52790	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	HK3	P52790	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	HK3	P52790	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	HK3	P52790	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	HK3	P52790	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	HK3	P52790	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	HK3	P52790	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
Intra	HK3	P52790	CCT5	Homo sapiens	P48643	Y2H Array	32814053
Intra	HK3	P52790	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
Intra	HK3	P52790	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	HK3	P52790	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	HK3	P52790	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	HK3	P52790	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	HK3	P52790	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	HK3	P52790	PRPS1	Homo sapiens	P60891	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74881	HK3/Hexokinase-3 Protein, Human (sf9, His-GST)	P52790 (M1-V923)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170799	HNC-1664	Inhibitor	/	Unkown
HY-RS06194	HK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HK3	VGNC	VGNC:41700
Felis catus	HK3	VGNC	VGNC:67581
Rattus norvegicus	HK3	RGD	RGD:2798
Bos taurus	HK3	VGNC	VGNC:29866
Macaca mulatta	HK3	VGNC	VGNC:73476
Mus musculus	HK3	MGD	MGI:2670962
Others	HK3	NCBI

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