2. Gene
  3. HK3 - hexokinase 3 Gene

HK3 - hexokinase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HXK3; HKIII

Gene ID: 3101 | Gene type: protein coding

About HK3

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,880,869-176,899,346 (from NCBI)

This gene has 6 transcripts (splice variants), 129 orthologues and 4 paralogues. Biased expression in bone marrow (RPKM 50.3), spleen (RPKM 14.0) and 3 other tissues.

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes Hexokinase 3. Similar to hexokinases 1 and 2, this allosteric Enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

HK3 Products(1)

mRNA Protein Name
NM_002115.3 NP_002106.2 hexokinase-3
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables hexokinase activity IDA
IDA: Inferred from direct assay
8717435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HK3 Protein Structure

Hexokinase_1

Hexokinase_1: Hexokinase (28 - 231)

Hexokinase_2

Hexokinase_2: Hexokinase (237 - 475)

Hexokinase_1

Hexokinase_1: Hexokinase (480 - 675)

Hexokinase_2

Hexokinase_2: Hexokinase (677 - 916)

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  • 923 a.a.
Protein Preferred Names Protein Names

hexokinase-3

ATP:D-hexose 6-phosphotransferase

Recombinant HK3 Proteins

Cat. No. Product Name Accession Purity
HY-P74881 HK3/Hexokinase-3 Protein, Human (sf9, His-GST) P52790 (M1-V923) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06194 HK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HK3 VGNC VGNC:41700
Felis catus HK3 VGNC VGNC:67581
Rattus norvegicus HK3 RGD RGD:2798
Bos taurus HK3 VGNC VGNC:29866
Macaca mulatta HK3 VGNC VGNC:73476
Mus musculus HK3 MGD MGI:2670962
Others HK3 NCBI