HLA-DRB3 - major histocompatibility complex, class II, DR beta 3 Gene

Homo sapiens

Also known as DRB3; HLA-DPB1; HLA-DR1B; HLA-DR3B; HLA-DRB3*

Gene ID: 3125 | Gene type: protein coding

About HLA-DRB3

Cytogenetic location: 6p21.3 Genomic coordinates (GRCh38): 6:30,500,001-36,600,000

Summary

HLA-DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting Peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene. [provided by RefSeq, Feb 2020]

HLA-DRB3 Products(1)

mRNA	Protein	Name
NM_022555.3	NP_072049.2	major histocompatibility complex, class II, DR beta 3 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptide antigen binding	IDA IDA: Inferred from direct assay	17583734	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	32341563	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IDA IDA: Inferred from direct assay	19531622	GOA
involved in myeloid dendritic cell antigen processing and presentation	IDA IDA: Inferred from direct assay	19531622	GOA
involved in positive regulation of CD4-positive, alpha-beta T cell activation	IDA IDA: Inferred from direct assay	19531622	GOA
involved in positive regulation of T cell mediated immune response to tumor cell	IDA IDA: Inferred from direct assay	30282837	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in late endosome membrane	IDA IDA: Inferred from direct assay	18305173	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	18305173	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19531622	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HLA-DRB3 Protein Structure

MHC_II_beta

C1-set

0
100
200
266 a.a.

Protein Preferred Names

Protein Names

major histocompatibility complex, class II, DR beta 3

HLA DRB3

HLA-DRB3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HLA-DRB3	P79483	NEK7	Homo sapiens	Q8TDX7	Y2H Pooling	32814053
Intra	HLA-DRB3	P79483	NEK7	Homo sapiens	Q8TDX7	Validated Y2H	32814053
Intra	HLA-DRB3	P79483	NEK7	Homo sapiens	Q8TDX7	Y2H Array	32814053
Intra	HLA-DRB3	P79483	DLST	Homo sapiens	P36957	Validated Y2H	32814053
Intra	HLA-DRB3	P79483	DLST	Homo sapiens	P36957	Y2H Array	32814053
Intra	HLA-DRB3	P79483	DLST	Homo sapiens	P36957	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pityriasis Rosea

Pityriasis Circinata

Gibert Pityriasis

Wolfram Syndrome

Didmoad Syndrome	Didmoad
Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness	Wfs
Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness	Didmoadud
Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome	Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06212	HLA-DRB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Name
Email *

	Sorry, but the email address you supplied was invalid.