2. Gene
  3. Dyrk2 - dual specificity tyrosine phosphorylation regulated kinase 2 Gene

Dyrk2 - dual specificity tyrosine phosphorylation regulated kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 314862 | Gene type: protein coding

About Dyrk2

Primary_assembly 7: 54,349,610-54,380,106 reverse strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 208 orthologues, 11 paralogues and is associated with 1 phenotype. Biased expression in Muscle (RPKM 348.9), Thymus (RPKM 336.2) and 9 other tissues.

Summary

Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ribonucleoprotein complex and ubiquitin Ligase complex. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk2 Products(1)

mRNA Protein Name
NM_001108100.1 NP_001101570.1 dual specificity tyrosine-phosphorylation-regulated kinase 2

Dyrk2 Protein Structure

PKc_DYRK2_3

PKc_DYRK2_3: cd14224 (154 - 533)

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Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 2

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-105309 GSK-626616 Inhibitor 99.77% Unkown
HY-112296 T025 Inhibitor 98.84% Unkown
HY-U00439A Protein kinase inhibitor 1 hydrochloride Inhibitor ≥98.0% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.56% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-13455 LDN-192960 Inhibitor 99.56% Unkown
HY-147066 Dyrk1A-IN-4 Inhibitor 99.90% Unkown
HY-156816 ON 108600 Inhibitor 99.73% Unkown
HY-153949 YK-2-69 Inhibitor 99.57% Unkown
HY-162750 ZJCK-6-46 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk2 NCBI NCBI:8445