2. Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. CDK DYRK
  4. MU1210

MU1210 (compound 12f) is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), and its IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax = 1.24 μM, T1/2 = 58 minutes; no acute toxicity observed).

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MU1210 Chemical Structure

MU1210 Chemical Structure

CAS No. : 2275601-87-9

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MU1210 Related Antibodies

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DYRK1 DYRK2 DYRK3 DYRK4

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Description

MU1210 (compound 12f) is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), and its IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax = 1.24 μM, T1/2 = 58 minutes; no acute toxicity observed)[1].

IC50 & Target

CLK1

8 nM (IC50)

CLK2

20 nM (IC50)

CLK4

12 nM (IC50)

HIPK1

187 nM (IC50)

DYRK2

1309 nM (IC50)

Molecular Weight

352.39

Formula

C22H16N4O
CAS No.
SMILES

CN1N=CC(C2=NC3=C(C=C2)OC=C3C4=CC=CC(C5=CC=NC=C5)=C4)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MU1210 Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MU12102275601-87-9MU 1210MU-1210CDKDYRKCyclin dependent kinaseDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasepharmacokinetic characteristicsmicecancerInhibitorinhibitorinhibit

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