2. PI3K/Akt/mTOR Stem Cell/Wnt Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. GSK-3 β-catenin DYRK JNK CDK CDKL
  4. GSK3-IN-10

GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress.

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GSK3-IN-10 Chemical Structure

GSK3-IN-10 Chemical Structure

CAS No. : 844441-56-1

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GSK3-IN-10 Related Antibodies

Top Publications Citing Use of Products

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GSK-3 GSK-3α GSK-3β

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DYRK1 DYRK2 DYRK3 DYRK4

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JNK1 JNK2 JNK3 JNK

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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Description

GSK3-IN-10 (Compound 4) is a multi-target inhibitor, that mainly targets GSK3α and GSK3β with IC50 of 1.0 nM and 2.0 nM. GSK3-IN-10 inhibits the activation of β-catenin, promotes the neuronal survival, and exhibits a protective effect against endoplasmic reticulum stress[1].

IC50 & Target

GSK-3α

1.0 nM (IC50)

GSK-3β

2.0 nM (IC50)

DYRK1B

47 nM (IC50)

DYRK1A

170 nM (IC50)

ICK

520 nM (IC50)

CLK1

620 nM (IC50)

CLK4

760 nM (IC50)

DYRK2

800 nM (IC50)

CLK2

800 nM (IC50)

CDKL5

840 nM (IC50)

JNK3

2900 nM (IC50)

CDK4

3800 nM (IC50)

Molecular Weight

364.35

Formula

C17H18F2N4O3
CAS No.
SMILES

O=C(C1=NNC=C1NC(C2=C(F)C=CC=C2F)=O)NCC3CCOCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK3-IN-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK3-IN-10844441-56-1GSK-3β-cateninDYRKJNKCDKCDKLGlycogen synthase kinase-3Glycogen synthase kinase 3Beta cateninDual specificity tyrosine phosphorylation regulated kinaseDual specificity tyrosine regulated kinasec-Jun N-terminal kinaseCyclin dependent kinaseCyclin-dependent kinase-like familyInhibitorinhibitorinhibit

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HY-172198
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