FOXA1 - forkhead box A1 Gene

Homo sapiens

Also known as HNF3A; TCF3A

Gene ID: 3169 | Gene type: protein coding

About FOXA1

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:37,589,552-37,595,249 (from NCBI)

This gene has 5 transcripts (splice variants), 147 orthologues, 42 paralogues and is associated with 71 phenotypes. Biased expression in prostate (RPKM 46.5), urinary bladder (RPKM 12.0) and 6 other tissues.

Summary

This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]

FOXA1 Products(1)

mRNA	Protein	Name
NM_004496.5	NP_004487.2	hepatocyte nuclear factor 3-alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9931457	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	25802280	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22722839	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16087863	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20160041	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	16087863	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	19127412	GOA
involved in positive regulation of intracellular estrogen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16087863	GOA
involved in positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16087863	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16331276	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16087863	GOA
involved in response to estradiol	IDA IDA: Inferred from direct assay	16087863	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9931457	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXA1 Protein Structure

Forkhead_N

Forkhead

HNF_C

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

hepatocyte nuclear factor 3-alpha

HNF-3-alpha

Related Diseases

Diseases

Alias

Miliaria Profunda

Icd10cm:L74.2

Snomedct_us_2020_03_01:47317002

Apocrine Sweat Gland Neoplasm

Apocrine Tumor

Apocrine Neoplasm

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Breast Lobular Carcinoma

Cancer, Breast, Lobular

Lobular Breast Carcinoma

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma	Adenocarcinoma Of Prostate
ST12	Prostate Adenocarcinoma 1
Pac1

Estrogen-Receptor Negative Breast Cancer

Estrogen-Receptor Positive Breast Cancer

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Colon Leiomyoma

Colonic Leiomyoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156190A	NR2F2-IN-1 free base		99.34%	Unkown
HY-RS05036	FOXA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-156190	NR2F2-IN-1		/	Unkown
HY-168534	WX-02-23		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXA1	VGNC	VGNC:53490
Rattus norvegicus	FOXA1	RGD	RGD:2807
Mus musculus	FOXA1	MGD	MGI:1347472
Bos taurus	FOXA1	VGNC	VGNC:29077
Macaca mulatta	FOXA1	VGNC	VGNC:72707
Felis catus	FOXA1	VGNC	VGNC:67600

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