NR2F2-IN-1 free base

Cat. No.: HY-156190A Purity: 99.34%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

NR2F2-IN-1 (free base) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F2-IN-1 (free base) substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F2-IN-1 (free base) directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.

For research use only. We do not sell to patients.

NR2F2-IN-1 free base Chemical Structure

CAS No. : 452087-38-6

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 750	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of NR2F2-IN-1 free base:

NR2F2-IN-1 Get quote

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Purity & Documentation
References
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Description

Molecular Weight

329.42

Formula

C₁₇H₁₉N₃O₂S

CAS No.

452087-38-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (379.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0356 mL	15.1782 mL	30.3564 mL
5 mM	0.6071 mL	3.0356 mL	6.0713 mL
10 mM	0.3036 mL	1.5178 mL	3.0356 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (250 KB) HNMR (257 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Leiming Wang, et al. Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment. Sci Adv. 2020 Apr 29;6(18):eaaz8031. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0356 mL	15.1782 mL	30.3564 mL	75.8910 mL
	5 mM	0.6071 mL	3.0356 mL	6.0713 mL	15.1782 mL
	10 mM	0.3036 mL	1.5178 mL	3.0356 mL	7.5891 mL
	15 mM	0.2024 mL	1.0119 mL	2.0238 mL	5.0594 mL
	20 mM	0.1518 mL	0.7589 mL	1.5178 mL	3.7945 mL
	25 mM	0.1214 mL	0.6071 mL	1.2143 mL	3.0356 mL
	30 mM	0.1012 mL	0.5059 mL	1.0119 mL	2.5297 mL
	40 mM	0.0759 mL	0.3795 mL	0.7589 mL	1.8973 mL
	50 mM	0.0607 mL	0.3036 mL	0.6071 mL	1.5178 mL
	60 mM	0.0506 mL	0.2530 mL	0.5059 mL	1.2648 mL
	80 mM	0.0379 mL	0.1897 mL	0.3795 mL	0.9486 mL
	100 mM	0.0304 mL	0.1518 mL	0.3036 mL	0.7589 mL