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  4. NR2F2-IN-1

NR2F6 modulator-2 (CIA1) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F6 modulator-2 substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F6 modulator-2 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.

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NR2F2-IN-1 Chemical Structure

NR2F2-IN-1 Chemical Structure

CAS No. : 1049691-47-5

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Description

NR2F6 modulator-2 (CIA1) is a potent and selective orphan nuclear receptor COUP-TFII (NR2F2) inhibitor. NR2F6 modulator-2 substantially inhibits COUP-TFII–driven NGFIA reporter expression. NR2F6 modulator-2 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation[1].

Molecular Weight

365.88

Formula

C17H20ClN3O2S
CAS No.
SMILES

COC(C(OC)=C1)=CC=C1CCNC2=C3C=C(C)SC3=NC=N2.Cl
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Keywords:

NR2F2-IN-11049691-47-5OthersCOUP-TFII ,NR2F2orphan nuclear receptorInhibitorinhibitorinhibit

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