Gpr4 - G protein-coupled receptor 4 Gene

Mus musculus

Gene ID: 319197 | Gene type: protein coding

About Gpr4

Chromosome 7: 18,946,463-18,958,099 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant), 141 orthologues, 16 paralogues and is associated with 30 phenotypes. Ubiquitous expression in lung adult (RPKM 11.4), subcutaneous fat pad adult (RPKM 11.1) and 25 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in positive regulation of inflammatory response and regulation of vascular permeability. Acts upstream of or within several processes, including blood vessel development; negative regulation of angiogenesis; and response to acidic pH. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Gpr4 Products(1)

mRNA	Protein	Name
NM_175668.4	NP_783599.1	G-protein coupled receptor 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	17145776	MGI
enables G protein-coupled receptor activity	IMP IMP: Inferred from mutant phenotype	17145776	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	17145776	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17145776	MGI
acts upstream of or within angiogenesis involved in wound healing	IDA IDA: Inferred from direct assay	17145776	MGI
acts upstream of or within glomerular mesangial cell development	IMP IMP: Inferred from mutant phenotype	17145776	MGI
acts upstream of or within negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17145776	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	32058960	MGI
involved in regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	32058960	MGI
acts upstream of or within response to acidic pH	IDA IDA: Inferred from direct assay	17145776	MGI
acts upstream of or within response to acidic pH	IMP IMP: Inferred from mutant phenotype	17145776	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpr4 Protein Structure

7tmA_GPR4

0
100
200
300
365 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101784	NE 52-QQ57		99.89%	Unkown
HY-101536	GPR4 antagonist 1	Antagonist	98.92%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpr4	NCBI	NCBI:2828

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