2. Gene
  3. HRC - histidine rich calcium binding protein Gene

HRC - histidine rich calcium binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3270 | Gene type: protein coding

About HRC

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,151,198-49,155,396 (from NCBI)

This gene has 4 transcripts (splice variants) and 87 orthologues. Restricted expression toward heart (RPKM 206.9).

Summary

This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR. [provided by RefSeq, Sep 2008]

HRC Products(1)

mRNA Protein Name
NM_002152.3 NP_002143.1 sarcoplasmic reticulum histidine-rich calcium-binding protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
17526652 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
24125847 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17526652 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
17526652 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of heart contraction IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in positive regulation of heart rate IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in positive regulation of relaxation of cardiac muscle IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of calcium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of cell communication by electrical coupling involved in cardiac conduction IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of cytosolic calcium ion concentration IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of heart rate IMP
IMP: Inferred from mutant phenotype
18617481 GOA
involved in regulation of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IGI
IGI: Inferred from genetic interaction
24125847 GOA
involved in regulation of ryanodine-sensitive calcium-release channel activity IGI
IGI: Inferred from genetic interaction
24125847 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
24125847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HRC Protein Structure

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (214 - 228)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (238 - 252)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (271 - 285)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (295 - 309)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (319 - 328)

Hist_rich_Ca-bd

Hist_rich_Ca-bd: Histidine-rich Calcium-binding repeat region (343 - 356)

  • 0
  • 200
  • 400
  • 600
  • 699 a.a.
Protein Preferred Names Protein Names

sarcoplasmic reticulum histidine-rich calcium-binding protein

HRC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
HRC P23327 ZNF699 Homo sapiens Q32M78
Y2H Prey Pooling
32296183
Intra
HRC P23327 ZNF699 Homo sapiens Q32M78
Y2H Array
32296183
Intra
HRC P23327 ZNF699 Homo sapiens Q32M78
Validated Y2H
32296183
Cross
HRC P23327 Ryr2 Mus musculus E9Q401
Confocal
24805197
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06357 HRC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HRC VGNC VGNC:41783
Bos taurus HRC VGNC VGNC:29952
Rattus norvegicus HRC RGD RGD:727864
Macaca mulatta HRC VGNC VGNC:73520
Mus musculus HRC MGD MGI:96226
Others HRC NCBI