HSD17B2 - hydroxysteroid 17-beta dehydrogenase 2 Gene

Homo sapiens

Also known as HSD17; SDR9C2; EDH17B2

Gene ID: 3294 | Gene type: protein coding

About HSD17B2

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:82,035,253-82,098,534 (from NCBI)

This gene has 6 transcripts (splice variants), 171 orthologues and 25 paralogues. Biased expression in duodenum (RPKM 177.2), placenta (RPKM 169.8) and 6 other tissues.

Summary

Enables estradiol 17-beta-dehydrogenase activity and testosterone dehydrogenase (NAD+) activity. Involved in response to retinoic acid. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

HSD17B2 Products(1)

mRNA	Protein	Name
NM_002153.3	NP_002144.1	17-beta-hydroxysteroid dehydrogenase type 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	8099587	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables testosterone dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	8099587	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in androgen metabolic process	IDA IDA: Inferred from direct assay	11940569	GOA
involved in estrogen biosynthetic process	IDA IDA: Inferred from direct assay	11940569	GOA
involved in response to retinoic acid	IDA IDA: Inferred from direct assay	17538076	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10385431	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B2 Protein Structure

adh_short

0
100
200
300
387 a.a.

Protein Preferred Names

Protein Names

17-beta-hydroxysteroid dehydrogenase type 2

17-beta-HSD 2

Related Diseases

Diseases

Alias

Progesterone Resistance

Pseudocorpus Luteum Insufficiency

Endometriosis Of Ovary

Ovarian Endometriosis

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06395	HSD17B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HSD17B2	VGNC	VGNC:41805
Macaca mulatta	HSD17B2	VGNC	VGNC:99512
Bos taurus	HSD17B2	VGNC	VGNC:29973
Mus musculus	HSD17B2	MGD	MGI:1096386
Felis catus	HSD17B2	VGNC	VGNC:67657
Rattus norvegicus	HSD17B2	RGD	RGD:621803

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