HTR2B - 5-hydroxytryptamine receptor 2B Gene

Homo sapiens

Also known as 5-HT2B; 5-HT-2B; 5-HT(2B)

Gene ID: 3357 | Gene type: protein coding

About HTR2B

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,108,230-231,125,042 (from NCBI)

This gene has 1 transcript (splice variant), 205 orthologues and 8 paralogues. Biased expression in endometrium (RPKM 10.3), adrenal (RPKM 7.1) and 8 other tissues.

Summary

This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

HTR2B Products(2)

mRNA	Protein	Name
NM_000867.5	NP_000858.3	5-hydroxytryptamine receptor 2B isoform 1
NM_001320758.2	NP_001307687.1	5-hydroxytryptamine receptor 2B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	7582481	GOA
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	15625277	GOA
enables G-protein alpha-subunit binding	IMP IMP: Inferred from mutant phenotype	15625277	GOA
enables Gq/11-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	18703043	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28258217	GOA
enables serotonin binding	IDA IDA: Inferred from direct assay	7582481	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	30127358	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19308295	GOA
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15625277	GOA
involved in G protein-coupled serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	7926008	GOA
involved in G protein-coupled serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18703043	GOA
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12970106	GOA
involved in calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	8882600	GOA
involved in intestine smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	7599919	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	19057895	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	12970106	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20099302	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19057895	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15625277	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15925089	GOA
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	19023134	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19308295	GOA
involved in positive regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	19057895	GOA
involved in regulation of behavior	IMP IMP: Inferred from mutant phenotype	21179162	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	15862800	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	8882600	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	15862800	GOA
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	15625277	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of G protein-coupled serotonin receptor complex	IDA IDA: Inferred from direct assay	7926008	GOA
part of G protein-coupled serotonin receptor complex	IMP IMP: Inferred from mutant phenotype	15625277	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15925089	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	7926008	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR2B Protein Structure

7tm_1

0
100
200
300
400
481 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 2B

5-HT 2B receptor

Related Diseases

Diseases

Alias

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Chronic Pulmonary Heart Disease

Intermittent Explosive Disorder

Explosive Personality Disorder

Pulmonary Valve Insufficiency

Pulmonary Regurgitation	Pulmonary Incompetence
Pulmonary Incompetence, Non-Rheumatic	Pulmonary Insufficiency Following Trauma And Surgery
Pulmonary Regurg.	Pulmonic Insufficiency
Pulmonic Valve Regurgitation	Pulmonary Valve Incompetence
Pulmonary Valve Incompetency	Pulmonary Valvular Insufficiency
Pulmonary Valvular Regurgitation	Pulmonary Valvular Incompetency
Pulmonary Valve Incompetence Nos	Annular Incompetency Pulmonary Valve
Incompetent Pulmonary Valve	Graham Steell Murmur
Pulmonary Valvular Incompetence

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-169229	GM-60186	Inhibitor	/	Unkown
HY-RS06468	HTR2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HTR2B	RGD	RGD:61801
Bos taurus	HTR2B	VGNC	VGNC:29997
Macaca mulatta	HTR2B	VGNC	VGNC:73540
Felis catus	HTR2B	VGNC	VGNC:67672
Canis familiaris	HTR2B	VGNC	VGNC:41827
Mus musculus	HTR2B	MGD	MGI:109323

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