HTR2C - 5-hydroxytryptamine receptor 2C Gene

Homo sapiens

Also known as HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C

Gene ID: 3358 | Gene type: protein coding

About HTR2C

Cytogenetic location: Xq23 Genomic coordinates (GRCh38): X:114,584,086-114,910,061 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues and 8 paralogues. Restricted expression toward brain (RPKM 1.3).

Summary

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]

HTR2C Products(3)

mRNA	Protein	Name
NM_000868.4	NP_000859.2	5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256760.3	NP_001243689.2	5-hydroxytryptamine receptor 2C isoform a precursor
NM_001256761.3	NP_001243690.2	5-hydroxytryptamine receptor 2C isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding	IDA IDA: Inferred from direct assay	19057895	GOA
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	7582481	GOA
enables Gq/11-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	18703043	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15518545	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14988405	GOA
enables serotonin binding	IDA IDA: Inferred from direct assay	7582481	GOA
enables serotonin receptor activity	IDA IDA: Inferred from direct assay	29398112	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	18703043	GOA
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	12970106	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	19057895	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	12970106	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19057895	GOA
involved in positive regulation of phosphatidylinositol biosynthetic process	IDA IDA: Inferred from direct assay	19057895	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	18703043	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of G protein-coupled serotonin receptor complex	IDA IDA: Inferred from direct assay	12970106	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12970106	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	18703043	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR2C Protein Structure

7tm_1

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 2C

5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled

HTR2C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HTR2C	P28335	TMBIM6	Homo sapiens	P55061	Validated Y2H	32296183
Intra	HTR2C	P28335	MTNR1B	Homo sapiens	P49286	BRET	25770211
Intra	HTR2C	P28335	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	HTR2C	P28335	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	HTR2C	P28335	TMEM147	Homo sapiens	Q9BVK8	Anti Tag CoIP	33961781
Intra	HTR2C	P28335	TMEM147	Homo sapiens	Q9BVK8	Anti Tag CoIP	28514442
Intra	HTR2C	P28335	EMP1	Homo sapiens	P54849	Validated Y2H	32296183
Intra	HTR2C	P28335	HTR2A	Homo sapiens	P28223	PLA	30157263
Intra	HTR2C	P28335	HTR2A	Homo sapiens	P28223	BRET	30157263
Intra	HTR2C	P28335	HTR2B	Homo sapiens	P41595	BRET	28258217
Intra	HTR2C	P28335	HTR2B	Homo sapiens	P41595	Anti Tag CoIP	28258217
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Anti Tag CoIP	28258217
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	BRET	25770211
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	FRET	16195233
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Crosslink	16195233
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	FRET	15518545
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	BRET	15518545
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Crosslink	15518545
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	BRET	28258217
Intra	HTR2C	P28335	HTR2C	Homo sapiens	P28335	Confocal	16195233

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Premature Ejaculation

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Borderline Personality Disorder

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Hyperprolactinemia

Chiari-Frommel Syndrome	Hyperprolactinaemia
Familial Hyperprolactinemia	HPRL
Pregnancy-Related A-G Syndrome	Familial Isolated Prolactin Receptor Deficiency

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Bulimia Nervosa

Bulimia	Bulimia Nervosa, Susceptibility To
Binge Eating Disorder	BULN
Bn	Hyperorexia Nervosa
Bulimia Nervosa 2	BULN2
Susceptibility To Bulimia Nervosa	Bulimia Nervosa, Susceptibility To, Type 2
Bn - [Bulimia Nervosa]	Bulimia Nos
Bulimic	Bingeing
Binge Overeating	Bouts Of Overeating
Episodes Of Overeating

Bipolar I Disorder

Manic Depression Nos	Manic-Depressive Illness
Bipolar Disorder Nos

Generalized Anxiety Disorder

Anxiety Generalized

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Psychosexual Disorder

Psychosexual Disorders

Delusional Disorder

Persistent Delusional Disorders	Delusional Perception
Induced Delusional Disorder

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Sexual Health Disorder

Sexual Health

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Sleep Apnea

Sleep Apnea Syndromes

High Pressure Neurological Syndrome

Lingual-Facial-Buccal Dyskinesia

Orofacial Dyskinesia	Oro-Facial Dyskinesia
Dyskinesias

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Hypochondriasis

Hypochondriacal Disorder	Hypochondria
Hypochondriacal Neurosis	Illness Anxiety Disorder
Health Anxiety Disorder	Hypochondriacal Reaction

Angelman Syndrome

AS	Happy Puppet Syndrome
Happy Puppet Syndrome, Formerly	Puppetlike Syndrome

Hypoactive Sexual Desire Disorder

Lack Or Loss Of Sexual Desire

Sexual Dysfunctions, Psychological

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Neurotic Disorder

Neurosis	Reactive Depression
Adjustment Disorders	Neurotic Disorders
Depressive Neurosis	Neurotic Depression
Neurotic Depression Reactive Type	Neurotic Depressive State
Psychoneurosis	Depressive Disorder
Depression, Neurotic

Mental Depression

Depression

Depressive Disorder

Paranoid Schizophrenia

Chronic Paranoid Schizophrenia	Paranoid Type Schizophrenia
Paranoid Type Schizophrenia Subchronic State	Paraphrenia - Late
Paraphrenic Schizophrenia	Schizophrenia, Paranoid

Intermittent Explosive Disorder

Explosive Personality Disorder

Schizophreniform Disorder

Schizophreniform Disorders

Psychotic Disorders

Dysthymic Disorder

Dysthymia	Chronic Depressive Disorder
Chronic Depression	Depressive Personality
Depressive Personality Disorder	Persistent Depressive Disorder
Persistent Depression

Drug Psychosis

Drug-Induced Psychosis	Drug-Induced Psychotic Disorder
Psychoses, Substance-Induced	Psychoses, Drug

Drug-Induced Mental Disorder

Oppositional Defiant Disorder

Disorder	Oppositional Defiance
Behavioural Disorder	Oppositional Defiance
Disruptive Mood Dysregulation Disorder

Substance-Induced Psychosis

Endogenous Depression

Clinical Depression	Unipolar Depression
Depressive Disorder

Bruxism

Sleep Bruxism	Sleep-Related Bruxism
Bruxism - Teeth Grinding	Grinding Teeth
Sleep Related Bruxism	Teeth Grinding
Sleep Related Teeth Grinding

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Disease Of Mental Health

Mental Health

Mental Disorders

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06469	HTR2C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HTR2C	RGD	RGD:2848
Canis familiaris	HTR2C	VGNC	VGNC:41828
Macaca mulatta	HTR2C	VGNC	VGNC:73541
Mus musculus	HTR2C	MGD	MGI:96281