ANO9 - anoctamin 9 Gene

Homo sapiens

Also known as PIG5; TP53I5; TMEM16J

Gene ID: 338440 | Gene type: protein coding

About ANO9

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:417,938-442,011 (from NCBI)

This gene has 8 transcripts (splice variants), 253 orthologues and 10 paralogues. Broad expression in skin (RPKM 19.3), duodenum (RPKM 19.0) and 14 other tissues.

Summary

The protein encoded by this gene is a member of the TMEM16 (anoctamin) family of proteins, some of which form integral membrane calcium-activated chloride channels. The function of the encoded protein has yet to be elucidated, although it may have channel-forming abilities and also may have phospholipid scramblase activity. This gene has been observed to be upregulated in stage II and III colorectal cancers. [provided by RefSeq, Dec 2016]

ANO9 Products(2)

mRNA	Protein	Name
NM_001012302.3	NP_001012302.2	anoctamin-9 isoform 1
NM_001347882.2	NP_001334811.1	anoctamin-9 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	36520003	GOA
enables channel activity	IDA IDA: Inferred from direct assay	29604966	GOA
enables chloride channel inhibitor activity	IDA IDA: Inferred from direct assay	22946059	GOA
NOT enables intracellularly calcium-gated chloride channel activity	IDA IDA: Inferred from direct assay	21984732	GOA
enables intracellularly calcium-gated chloride channel activity	IMP IMP: Inferred from mutant phenotype	22946059	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21525870	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chloride transmembrane transport	IMP IMP: Inferred from mutant phenotype	22946059	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	36520003	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22946059	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANO9 Protein Structure

Anoctamin

0
200
400
600
782 a.a.

Protein Preferred Names

Protein Names

anoctamin-9

p53-induced gene 5 protein

ANO9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANO9	A1A5B4	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	ANO9	A1A5B4	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	ANO9	A1A5B4	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Scott Syndrome

SCTS	Bdplt7
Prothrombin Consumption Deficiency	Bleeding Abnormality Due To Deficiency Of Platelet Binding Of Factor X
Bleeding Disorder, Platelet-Type, 7	Prothrombin Conversion Defect, Familial
Prothrombin Consumption Inhibitor, Familial	Bleeding Abnormality Due To Deficiency Of Platelet Biding Of Factor X
Familial Prothrombin Consumption Inhibitor	Familial Prothrombin Conversion Defect
Platelet-Type Bleeding Disorder 7	Platelet Factor X Receptor Deficiency
Bleeding Disorder Platelet-Type 7	Prothrombin Consumption Inhibitor Familial
Prothrombin Conversion Defect Familial

Gnathodiaphyseal Dysplasia

GDD	Osteogenesis Imperfecta With Unusual Skeletal Lesions
Gnathodiaphyseal Sclerosis	Osteogenesis Imperfecta, Levin Type
Levin Syndrome 2	Dysplasia, Gnathodiaphyseal

Spinocerebellar Ataxia, Autosomal Recessive 10

SCAR10	Autosomal Recessive Spinocerebellar Ataxia 10
Adult-Onset Autosomal Recessive Cerebellar Ataxia	Autosomal Recessive Spinocerebellar Ataxia Type 10
Spinocerebellar Ataxia, Autosomal Recessive, 10	Ataxia, Spinocerebellar, Autosomal Recessive, Type 10

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10	SCA10
Spinocerebellar Ataxia-10	Ataxia, Spinocerebellar, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00749	ANO9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ANO9	RGD	RGD:1560565
Bos taurus	ANO9	VGNC	VGNC:106640
Mus musculus	ANO9	MGD	MGI:1918595
Canis familiaris	ANO9	VGNC	VGNC:37931
Felis catus	ANO9	VGNC	VGNC:59834

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