Gpbar1 - G protein-coupled bile acid receptor 1 Gene

Rattus norvegicus

Also known as Tgr5; M-BAR

Gene ID: 338443 | Gene type: protein coding

About Gpbar1

Primary_assembly 9: 75,860,677-75,863,168 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 75 orthologues and is associated with 12 phenotypes. Biased expression in Kidney (RPKM 11.), Lung (RPKM 9.7) and 9 other tissues.

Summary

Enables G protein-coupled receptor activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of cholangiocyte proliferation. Predicted to be located in cytoplasm and plasma membrane. Predicted to be part of receptor complex. Biomarker of non-alcoholic steatohepatitis and polycystic kidney disease. Orthologous to human GPBAR1 (G protein-coupled Bile Acid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Gpbar1 Products(2)

mRNA	Protein	Name
NM_177936.2	NP_808797.1	G-protein coupled bile acid receptor 1
NM_177936.2	NP_808797.1	G-protein coupled bile acid receptor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	12524422	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	28543567	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	28543567	RGD
involved in positive regulation of cholangiocyte proliferation	IMP IMP: Inferred from mutant phenotype	28543567	RGD
involved in positive regulation of cholangiocyte proliferation	IMP IMP: Inferred from mutant phenotype	28543567	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gpbar1 Protein Structure

7tm_GPCRs

0
100
200
300
329 a.a.

Protein Preferred Names

Protein Names

G-protein coupled bile acid receptor 1

G protein-coupled receptor

membrane-type receptor for bile acids

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Agonist	Purity	Phase Phase 1
HY-101273	BAR502	Agonist	99.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect Agonist Pre-designed Sets Antagonist	Purity	Rare Diseases Unkown
HY-101274	BAR501	Agonist	≥98.0%	Unkown
HY-147086	CAY10789		99.84%	Unkown
HY-145234	GPBAR1-IN-3		/	Unkown
HY-107612	GPBAR-A	Agonist	/	Unkown
HY-146453	TGR5 Receptor Agonist 3	Agonist	/	Unkown
HY-168329	TGR5 agonist 7	Agonist	/	Unkown
HY-RS05622	GPBAR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05623	Gpbar1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05624	Gpbar1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-101274A	(3α,5β,6β,7α)-BAR501		/	Unkown
HY-165155	CysLT1 receptor antagonist-1	Antagonist	/	Unkown
HY-168784	LTD4 antagonist 2	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpbar1	NCBI	NCBI:151306

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