RXFP4 - relaxin family peptide/INSL5 receptor 4 Gene

Homo sapiens

Also known as GPR100; RLN3R2; RXFPR4; GPCR142

Gene ID: 339403 | Gene type: protein coding

About RXFP4

Cytogenetic location: 1q22 Genomic coordinates (GRCh38): 1:155,941,638-155,943,087 (from NCBI)

This gene has 1 transcript (splice variant), 105 orthologues and 7 paralogues.

Summary

GPR100 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]

RXFP4 Products(1)

mRNA	Protein	Name
NM_181885.3	NP_871001.1	relaxin-3 receptor 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24802387	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXFP4 Protein Structure

7tm_1

0
100
200
300
374 a.a.

Protein Preferred Names

Protein Names

relaxin-3 receptor 2

G protein-coupled receptor 100

RXFP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RXFP4	Q8TDU9	GJA8	Homo sapiens	P48165	Y2H Array	32296183
Intra	RXFP4	Q8TDU9	GJA8	Homo sapiens	P48165	Y2H Prey Pooling	32296183
Intra	RXFP4	Q8TDU9	RLN3	Homo sapiens	Q8WXF3	Competition Binding	24802387

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Bile Acid Synthesis Defect

3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency	Cba
Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency	Basd
Bile Acid Synthesis Defect, Congenital, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145278	RXFP3/4 agonist 2		99.82%	Unkown
HY-RS12360	RXFP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RXFP4	MGD	MGI:2182926
Macaca mulatta	RXFP4	VGNC	VGNC:100126
Rattus norvegicus	RXFP4	RGD	RGD:2322332
Bos taurus	RXFP4	VGNC	VGNC:55676

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