2. GPCR/G Protein
  3. RXFP Receptor
  4. RXFP3/4 agonist 2

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM.

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RXFP3/4 agonist 2 Chemical Structure

RXFP3/4 agonist 2 Chemical Structure

CAS No. : 2752378-78-0

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Based on 1 publication(s) in Google Scholar

RXFP3/4 agonist 2 Related Antibodies

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Description

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].

Molecular Weight

402.45

Formula

C22H22N6O2
CAS No.
Appearance

Solid

Color

White to pink

SMILES

COC(C(C=C1)=CC=C1CCNC(N/N=C/C(C2=CC(C#N)=C3)=CNC2=C3C)=N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (248.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4848 mL 12.4239 mL 24.8478 mL
5 mM 0.4970 mL 2.4848 mL 4.9696 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.82%

COA (247 KB) HNMR (227 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4848 mL 12.4239 mL 24.8478 mL 62.1195 mL
5 mM 0.4970 mL 2.4848 mL 4.9696 mL 12.4239 mL
10 mM 0.2485 mL 1.2424 mL 2.4848 mL 6.2120 mL
15 mM 0.1657 mL 0.8283 mL 1.6565 mL 4.1413 mL
20 mM 0.1242 mL 0.6212 mL 1.2424 mL 3.1060 mL
25 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
30 mM 0.0828 mL 0.4141 mL 0.8283 mL 2.0707 mL
40 mM 0.0621 mL 0.3106 mL 0.6212 mL 1.5530 mL
50 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
60 mM 0.0414 mL 0.2071 mL 0.4141 mL 1.0353 mL
80 mM 0.0311 mL 0.1553 mL 0.3106 mL 0.7765 mL
100 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
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RXFP3/4 agonist 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RXFP3/4 agonist 22752378-78-0RXFP Receptornonpeptideamidinohydrazone-basedβ-arrestin-2interactionRXFP3RXFP4Inhibitorinhibitorinhibit

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