SLC35D3 - solute carrier family 35 member D3 Gene

Homo sapiens

Also known as FRCL1

Gene ID: 340146 | Gene type: protein coding

About SLC35D3

Cytogenetic location: 6q23.3 Genomic coordinates (GRCh38): 6:136,922,301-136,925,660 (from NCBI)

This gene has 1 transcript (splice variant), 196 orthologues and 9 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable antiporter activity and pyrimidine nucleotide-sugar transmembrane transporter activity. Predicted to be involved in carbohydrate transport and pyrimidine nucleotide-sugar transmembrane transport. Predicted to act upstream of or within energy homeostasis and positive regulation of protein exit from endoplasmic reticulum. Predicted to be located in early endosome and endoplasmic reticulum. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

SLC35D3 Products(1)

mRNA	Protein	Name
NM_001008783.3	NP_001008783.1	solute carrier family 35 member D3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables UDP-glucose transmembrane transporter activity	IDA IDA: Inferred from direct assay	34269178	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in UDP-glucose transmembrane transport	IDA IDA: Inferred from direct assay	34269178	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	34269178	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35D3 Protein Structure

TPT

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

solute carrier family 35 member D3

frc, fringe-like 1

Related Diseases

Diseases

Alias

Thrombocytopenia With Beta-Thalassemia, X-Linked

XLTT	Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome	Gata1-Related X-Linked Cytopenia
X-Linked Thrombocytopenia With Beta-Thalassemia	Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis

Prostate Small Cell Carcinoma

Small Cell Carcinoma Of Prostate

Prostate Oat Cell Carcinoma

Intellectual Developmental Disorder, Autosomal Dominant 56

Mental Retardation, Autosomal Dominant 56	MRD56
Autosomal Dominant Mental Retardation 56	Autosomal Dominant Intellectual Developmental Disorder 56
Autosomal Dominant Intellectual Developmental Disorder-56

Developmental And Epileptic Encephalopathy 48

DEE48	Epileptic Encephalopathy, Early Infantile, 48
Eiee48	Developmental And Epileptic Encephalopathy, 48
Early Infantile Epileptic Encephalopathy 48

Psoriasis 15

Psors15

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13203	SLC35D3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC35D3	VGNC	VGNC:34829
Rattus norvegicus	SLC35D3	RGD	RGD:1309428
Felis catus	SLC35D3	VGNC	VGNC:65328
Canis familiaris	SLC35D3	VGNC	VGNC:46372
Mus musculus	SLC35D3	MGD	MGI:1923407
Macaca mulatta	SLC35D3	VGNC	VGNC:104427

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