IFI16 - interferon gamma inducible protein 16 Gene

Homo sapiens

Also known as PYHIN2; IFNGIP1

Gene ID: 3428 | Gene type: protein coding

About IFI16

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,999,976-159,055,151 (from NCBI)

This gene has 13 transcripts (splice variants), 52 orthologues and 3 paralogues. Ubiquitous expression in lymph node (RPKM 45.3), appendix (RPKM 41.3) and 24 other tissues.

Summary

This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]

IFI16 Products(8)

mRNA	Protein	Name
NM_001206567.2	NP_001193496.1	gamma-interferon-inducible protein 16 isoform 1
NM_001364867.2	NP_001351796.1	gamma-interferon-inducible protein 16 isoform 3
NM_001376587.1	NP_001363516.1	gamma-interferon-inducible protein 16 isoform 3
NM_001376588.1	NP_001363517.1	gamma-interferon-inducible protein 16 isoform 2
NM_001376589.1	NP_001363518.1	gamma-interferon-inducible protein 16 isoform 2
NM_001376591.1	NP_001363520.1	gamma-interferon-inducible protein 16 isoform 4
NM_001376592.1	NP_001363521.1	gamma-interferon-inducible protein 16 isoform 4
NM_005531.3	NP_005522.2	gamma-interferon-inducible protein 16 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	7536752	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	9718316	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11146555	GOA
enables transcription factor binding	IDA IDA: Inferred from direct assay	12894224	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	21575908	GOA
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	21575908	GOA
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	21573174	GOA
involved in cellular response to ionizing radiation	IDA IDA: Inferred from direct assay	14654789	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	21478870	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	21575908	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	21573174	GOA
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA IDA: Inferred from direct assay	14654789	GOA
involved in monocyte differentiation	IDA IDA: Inferred from direct assay	9766636	GOA
involved in negative regulation of AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	30104205	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	22291595	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9642285	GOA
involved in negative regulation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	22046441	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24413532	GOA
involved in negative regulation of innate immune response	IDA IDA: Inferred from direct assay	22046441	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12894224	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22046441	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	22291595	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	21575908	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11146555	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21575908	GOA
involved in regulation of autophagy	IEP IEP: Inferred from expression pattern	21573174	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	30104205	GOA
colocalizes with cytosol	IPI IPI: Inferred from physical interaction	24531343	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	19158679	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	14654789	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	14654789	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7536752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFI16 Protein Structure

PYRIN

HIN

0
200
400
600
785 a.a.

Protein Preferred Names

Protein Names

gamma-interferon-inducible protein 16

interferon-gamma induced protein IFI 16

IFI16 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Confocal	14654789
Intra	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Anti Bait CoIP	14654789
Intra	IFI16	Q16666	BRCA1	Homo sapiens	P38398	Pull Down	14654789
Intra	IFI16	Q16666	AR	Homo sapiens	P10275	Anti Bait CoIP	16494870
Intra	IFI16	Q16666	AR	Homo sapiens	P10275	Pull Down	16494870
Intra	IFI16	Q16666	DHX58	Homo sapiens	Q96C10	Pull Down	30833792

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Herpes Simplex

Herpes Simplex Infections	Herpesvirus Hominis Disease
Herpes Simplex Disease	Herpesviral Infection Due To Herpes Simplex
Infections Due To Simplex Virus	Herpes Nos

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Sting-Associated Vasculopathy With Onset In Infancy

Savi	Sting-Associated Vasculopathy, Infantile Onset
Sting-Associated Vasculopathy, Infantile-Onset

Genital Herpes

Herpes Genitalis	Genital Herpes Simplex
Venereal Herpes	Virus-Genital Herpes

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-RS06552	IFI16 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IFI16	VGNC	VGNC:73562
Others	IFI16	NCBI

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