IFIT2 - interferon induced protein with tetratricopeptide repeats 2 Gene

Homo sapiens

Also known as P54; G10P2; IFI54; ISG54; cig42; IFI-54; IFIT-2; ISG-54; GARG-39; IFI-54K; ISG-54K; ISG-54 K

Gene ID: 3433 | Gene type: protein coding

About IFIT2

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,302,046-89,309,271 (from NCBI)

This gene has 15 transcripts (splice variants), 512 orthologues and 4 paralogues. Broad expression in bone marrow (RPKM 19.8), spleen (RPKM 15.9) and 24 other tissues.

Summary

Enables RNA binding activity. Involved in negative regulation of protein binding activity; positive regulation of apoptotic process; and response to virus. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

IFIT2 Products(1)

mRNA	Protein	Name
NM_001547.5	NP_001538.4	interferon-induced protein with tetratricopeptide repeats 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19416887	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	19416887	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	19416887	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	21190939	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	19416887	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	21642987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21190939	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	21190939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFIT2 Protein Structure

TPR_8

TPR_11

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

interferon-induced protein with tetratricopeptide repeats 2

Interferon, alpha-inducible protein (MW 54kD)

Related Diseases

Diseases

Alias

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06562	IFIT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IFIT2	MGD	MGI:99449
Felis catus	IFIT2	VGNC	VGNC:67698
Macaca mulatta	IFIT2	VGNC	VGNC:106062
Canis familiaris	IFIT2	VGNC	VGNC:41877
Rattus norvegicus	IFIT2	RGD	RGD:1307804
Bos taurus	IFIT2	VGNC	VGNC:30049

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