IFIT1 - interferon induced protein with tetratricopeptide repeats 1 Gene

Homo sapiens

Also known as C56; P56; G10P1; IFI56; ISG56; IFI-56; IFIT-1; IFNAI1; RNM561; IFI-56K

Gene ID: 3434 | Gene type: protein coding

About IFIT1

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:89,392,623-89,406,487 (from NCBI)

This gene has 2 transcripts (splice variants), 513 orthologues and 4 paralogues. Ubiquitous expression in adrenal (RPKM 10.7), spleen (RPKM 10.7) and 25 other tissues.

Summary

This gene encodes a protein containing tetratricopeptide repeats that was originally identified as induced upon treatment with interferon. The encoded protein may inhibit viral replication and translational initiation. This gene is located in a cluster on chromosome 10 with five Other closely related genes. There is a pseudogene for this gene on chromosome 13. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]

IFIT1 Products(5)

mRNA	Protein	Name
NM_001270927.2	NP_001257856.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 2
NM_001270928.2	NP_001257857.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 3
NM_001270929.2	NP_001257858.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 3
NM_001270930.2	NP_001257859.1	interferon-induced protein with tetratricopeptide repeats 1 isoform 3
NM_001548.5	NP_001539.3	interferon-induced protein with tetratricopeptide repeats 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	21642987	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	19008854	GOA
involved in antiviral innate immune response	IEP IEP: Inferred from expression pattern	25930096	GOA
involved in cellular response to exogenous dsRNA	IDA IDA: Inferred from direct assay	19008854	GOA
involved in cellular response to type I interferon	IDA IDA: Inferred from direct assay	19008854	GOA
involved in intracellular transport of viral protein in host cell	IDA IDA: Inferred from direct assay	19008854	GOA
involved in negative regulation of helicase activity	IDA IDA: Inferred from direct assay	19008854	GOA
involved in negative regulation of protein binding	IDA IDA: Inferred from direct assay	19416887	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19008854	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	19416887	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	19416887	GOA
involved in response to virus	IMP IMP: Inferred from mutant phenotype	21642987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19008854	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFIT1 Protein Structure

TPR_12

TPR_1

TPR_2

TPR_1

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

interferon-induced protein with tetratricopeptide repeats 1

interferon, alpha-inducible protein (MW 56kD)

IFIT1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IFIT1	P09914	IFIT2	Homo sapiens	P09913	Anti Tag CoIP	21642987
Cross	IFIT1	P09914	E1	Human papillomavirus	P06789	Anti Tag CoIP	19008854
Cross	IFIT1	P09914	E1	Human papillomavirus	P06789	IF	19008854
Cross	IFIT1	P09914	E1	Human papillomavirus	P06789	Anti Bait CoIP	19008854
Intra	IFIT1	P09914	IFIT3	Homo sapiens	O14879	GMS	21642987
Intra	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Y2H Array	25416956
Intra	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Anti Tag CoIP	21642987
Intra	IFIT1	P09914	IFIT3	Homo sapiens	O14879	BFG-2H	27107012
Intra	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Y2H Pooling	16189514
Intra	IFIT1	P09914	IFIT3	Homo sapiens	O14879	Validated Y2H	27107012

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Sting-Associated Vasculopathy With Onset In Infancy

Savi	Sting-Associated Vasculopathy, Infantile Onset
Sting-Associated Vasculopathy, Infantile-Onset

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Chilblain Lupus 1

Chilblain Lupus	CHBL1
Chilblain Lupus Erythematosus	Chle
Hutchinson Lupus	Chilblain Lupus, Type 1

Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations

Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations	Crv
Rvcl	Rvcl-S
Vasculopathy, Retinal, With Cerebral Leukodystrophy	Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Retinal Vasculopathy With Cerebral Leukodystrophy	Retinal Vasculopathy And Cerebral Leukoencephalopathy
Hereditary Vascular Retinopathy	Hvr
RVCLS	Cerebroretinal Vasculopathy, Hereditary
Cerebroretinal Vasculopathy	Herns
Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly	Hereditary Cerebroretinal Vasculopathy
Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke	Hereditary Systemic Angiopathy
Hsa	Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations
Adrvcl	Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy
Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke	Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123805	KIN1400		98.1%	Unkown
HY-RS06560	IFIT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06561	IFIT1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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