APOC4 - apolipoprotein C4 Gene

Homo sapiens

Also known as APO-CIV; APOC-IV

Gene ID: 346 | Gene type: protein coding

About APOC4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,942,237-44,945,496 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward liver (RPKM 124.3).

Summary

This gene encodes a lipid-binding protein belonging to the Apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with Other related Apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream Apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

APOC4 Products(1)

mRNA	Protein	Name
NM_001646.3	NP_001637.1	apolipoprotein C-IV precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of sequestering of triglyceride	IMP IMP: Inferred from mutant phenotype	18809223	GOA
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	8827523	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	12700345	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	12700345	GOA
part of very-low-density lipoprotein particle	IMP IMP: Inferred from mutant phenotype	8827523	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOC4 Protein Structure

APOC4

0
100
127 a.a.

Protein Preferred Names

Protein Names

apolipoprotein C-IV

APOC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOC4	P55056	SYT16	Homo sapiens	Q17RD7	Validated Y2H	32296183
Intra	APOC4	P55056	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	32296183
Intra	APOC4	P55056	MAIP1	Homo sapiens	Q8WWC4	Validated Y2H	32296183
Intra	APOC4	P55056	MICOS13	Homo sapiens	Q5XKP0	Validated Y2H	32296183
Intra	APOC4	P55056	GSDMA	Homo sapiens	Q96QA5	Validated Y2H	32296183
Intra	APOC4	P55056	RSAD2	Homo sapiens	Q8WXG1	Validated Y2H	32296183
Intra	APOC4	P55056	MICOS10	Homo sapiens	Q5TGZ0	Validated Y2H	32296183
Intra	APOC4	P55056	LETMD1	Homo sapiens	Q6P1Q0	Validated Y2H	32296183
Intra	APOC4	P55056	TPRG1	Homo sapiens	Q6ZUI0	Validated Y2H	32296183
Intra	APOC4	P55056	PORCN	Homo sapiens	Q9H237-2	Validated Y2H	32296183
Intra	APOC4	P55056	APOL2	Homo sapiens	Q9BQE5	Validated Y2H	32296183
Intra	APOC4	P55056	DIABLO	Homo sapiens	Q9NR28	Validated Y2H	32296183
Intra	APOC4	P55056	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	APOC4	P55056	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	APOC4	P55056	SENP2	Homo sapiens	Q9HC62	Validated Y2H	32296183
Intra	APOC4	P55056	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	APOC4	P55056	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	APOC4	P55056	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	APOC4	P55056	TBC1D20	Homo sapiens	Q96BZ9	Validated Y2H	32296183
Intra	APOC4	P55056	TBC1D20	Homo sapiens	Q96BZ9	Y2H Array	32296183
Intra	APOC4	P55056	GAD2	Homo sapiens	Q05329	Validated Y2H	32296183
Intra	APOC4	P55056	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv	Carbohydrate-Inducible Hyperlipemia
Endogenous Hyperlipidaemia	Familial Hypertriglyceridemia
Fredrickson Type Iv Hyperlipoproteinemia	Fredrickson Type Iv Lipidaemia
Fredrickson Type Iv Lipidemia	Vldl Hyperlipoproteinemia
Hyperlipoproteinemia Type 4	Carbohydrate Inducible Hyperlipemia
Familial Type Iv Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00847	APOC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOC4	MGD	MGI:87878
Felis catus	APOC4	VGNC	VGNC:103060
Canis familiaris	APOC4	VGNC	VGNC:53523
Bos taurus	APOC4	VGNC	VGNC:52177
Macaca mulatta	APOC4	VGNC	VGNC:109594
Rattus norvegicus	APOC4	RGD	RGD:70959

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