APOC4 - apolipoprotein C4 Gene

Homo sapiens

Also known as APO-CIV; APOC-IV

Gene ID: 346 | Gene type: protein coding

About APOC4

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,942,237-44,945,496 (from NCBI)

This gene has 2 transcripts (splice variants) and 77 orthologues. Restricted expression toward liver (RPKM 124.3).

Summary

This gene encodes a lipid-binding protein belonging to the apolipoprotein gene family. The protein is thought to play a role in lipid metabolism. Polymorphisms in this gene may influence circulating lipid levels and may be associated with coronary artery disease risk. This gene is present in a cluster with other related apolipoprotein genes on chromosome 19. Naturally occurring read-through transcription exists between this gene and the neighboring downstream apolipoprotein C-II (APOC2) gene. [provided by RefSeq, Mar 2011]

APOC4 Products(1)

mRNA	Protein	Name
NM_001646.3	NP_001637.1	apolipoprotein C-IV precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of sequestering of triglyceride	IMP IMP: Inferred from mutant phenotype	18809223	GOA
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	8827523	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	12700345	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	12700345	GOA
part of very-low-density lipoprotein particle	IMP IMP: Inferred from mutant phenotype	8827523	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOC4 Protein Structure

APOC4

0
100
127 a.a.

Protein Preferred Names

Protein Names

apolipoprotein C-IV

Related Diseases

Diseases

Alias

Hyperlipoproteinemia, Type Iv

Hyperlipoproteinemia Type Iv	Carbohydrate-Inducible Hyperlipemia
Endogenous Hyperlipidaemia	Familial Hypertriglyceridemia
Fredrickson Type Iv Hyperlipoproteinemia	Fredrickson Type Iv Lipidaemia
Fredrickson Type Iv Lipidemia	Vldl Hyperlipoproteinemia
Hyperlipoproteinemia Type 4	Carbohydrate Inducible Hyperlipemia
Familial Type Iv Hyperlipoproteinemia	Familial Hyperlipoproteinemia Type Iv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00847	APOC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOC4	MGD	MGI:87878
Felis catus	APOC4	VGNC	VGNC:103060
Canis familiaris	APOC4	VGNC	VGNC:53523
Bos taurus	APOC4	VGNC	VGNC:52177
Macaca mulatta	APOC4	VGNC	VGNC:109594
Rattus norvegicus	APOC4	RGD	RGD:70959

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