APOL2 - apolipoprotein L2 Gene

Homo sapiens

Also known as APOL3; APOL-II

Gene ID: 23780 | Gene type: protein coding

About APOL2

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,226,209-36,239,954 (from NCBI)

This gene has 9 transcripts (splice variants), 518 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in appendix (RPKM 11.5), spleen (RPKM 10.5) and 25 other tissues.

Summary

This gene is a member of the Apolipoprotein L gene family. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids or allow the binding of lipids to organelles. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

APOL2 Products(2)

mRNA	Protein	Name
NM_030882.4	NP_112092.2	apolipoprotein L2
NM_145637.3	NP_663612.2	apolipoprotein L2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOL2 Protein Structure

ApoL

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

apolipoprotein L2

apolipoprotein L, 2

APOL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOL2	Q9BQE5	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMED8	Homo sapiens	Q6PL24	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMED8	Homo sapiens	Q6PL24	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMEM179B	Homo sapiens	Q7Z7N9	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	TMEM179B	Homo sapiens	Q7Z7N9	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	MFF	Homo sapiens	Q9GZY8-5	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	MFF	Homo sapiens	Q9GZY8-5	Y2H Array	32296183
Intra	APOL2	Q9BQE5	MFF	Homo sapiens	Q9GZY8-5	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	APOL2	Q9BQE5	AIG1	Homo sapiens	Q9NVV5-2	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	AIG1	Homo sapiens	Q9NVV5-2	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	AIG1	Homo sapiens	Q9NVV5-2	Y2H Array	32296183
Intra	APOL2	Q9BQE5	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	SLC26A6	Homo sapiens	Q9BXS9-3	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	SLC26A6	Homo sapiens	Q9BXS9-3	Y2H Array	32296183
Intra	APOL2	Q9BQE5	SLC18A1	Homo sapiens	P54219-3	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	SLC18A1	Homo sapiens	P54219-3	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	APOL2	Q9BQE5	APOC4	Homo sapiens	P55056	Y2H Array	32296183
Intra	APOL2	Q9BQE5	APOC4	Homo sapiens	P55056	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	APOL2	Q9BQE5	GET1	Homo sapiens	O00258	Y2H Array	32296183
Intra	APOL2	Q9BQE5	GET1	Homo sapiens	O00258	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	MARCHF3	Homo sapiens	Q86UD3	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	MARCHF3	Homo sapiens	Q86UD3	Y2H Array	32296183
Intra	APOL2	Q9BQE5	CYBC1	Homo sapiens	Q9BQA9	Y2H Array	32296183
Intra	APOL2	Q9BQE5	CYBC1	Homo sapiens	Q9BQA9	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	TMEM60	Homo sapiens	Q9H2L4	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	GJB5	Homo sapiens	O95377	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	GJB5	Homo sapiens	O95377	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMEM45B	Homo sapiens	Q96B21	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	TMEM45B	Homo sapiens	Q96B21	Y2H Array	32296183
Intra	APOL2	Q9BQE5	EMP1	Homo sapiens	P54849	Y2H Array	32296183
Intra	APOL2	Q9BQE5	EMP1	Homo sapiens	P54849	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	SIT1	Homo sapiens	Q9Y3P8	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	SIT1	Homo sapiens	Q9Y3P8	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	SIT1	Homo sapiens	Q9Y3P8	Y2H Array	32296183
Intra	APOL2	Q9BQE5	PANX1	Homo sapiens	Q96RD7	Y2H Array	32296183
Intra	APOL2	Q9BQE5	PANX1	Homo sapiens	Q96RD7	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMEM139	Homo sapiens	Q8IV31	Y2H Array	32296183
Intra	APOL2	Q9BQE5	TMEM139	Homo sapiens	Q8IV31	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	MGST3	Homo sapiens	O14880	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	MGST3	Homo sapiens	O14880	Y2H Array	32296183
Intra	APOL2	Q9BQE5	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	APOL2	Q9BQE5	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	APOL2	Q9BQE5	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	APOL2	Q9BQE5	KCNA1	Homo sapiens	Q09470	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	KCNA1	Homo sapiens	Q09470	Y2H Array	32296183
Intra	APOL2	Q9BQE5	EBAG9	Homo sapiens	O00559	Y2H Prey Pooling	32296183
Intra	APOL2	Q9BQE5	EBAG9	Homo sapiens	O00559	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Phencyclidine Abuse

Pcp Abuse

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N13201	12-Deoxyphorbol 13-palmitate	Inducer	/	Unkown
HY-RS00854	APOL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	APOL2	VGNC	VGNC:69989
Rattus norvegicus	APOL2	RGD	RGD:1309591

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