SLC35B2 - solute carrier family 35 member B2 Gene

Homo sapiens

Also known as SLL; PAPST1; UGTrel4

Gene ID: 347734 | Gene type: protein coding

About SLC35B2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,254,101-44,257,890 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 17.2), thyroid (RPKM 15.1) and 25 other tissues.

Summary

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

SLC35B2 Products(9)

mRNA	Protein	Name
NM_001286509.2	NP_001273438.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286510.2	NP_001273439.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286511.2	NP_001273440.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286512.2	NP_001273441.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286513.2	NP_001273442.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform d precursor
NM_001286517.2	NP_001273446.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e
NM_001286519.2	NP_001273448.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_001286520.2	NP_001273449.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_178148.4	NP_835361.1	adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity	IDA IDA: Inferred from direct assay	12716889	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate transport	IDA IDA: Inferred from direct assay	12716889	GOA
involved in chondroitin sulfate biosynthetic process	IMP IMP: Inferred from mutant phenotype	35325049	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12716889	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	12716889	GOA
located in membrane	IDA IDA: Inferred from direct assay	12716889	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35B2 Protein Structure

UAA

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

adenosine 3'-phospho 5'-phosphosulfate transporter 1

3'-phosphoadenosine 5'-phosphosulfate transporter

Related Diseases

Diseases

Alias

Primary Bone Dysplasia With Multiple Joint Dislocations

Primary Osteodysplasia With Multiple Joint Dislocations

Primary Skeletal Dysplasia With Multiple Joint Dislocations

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13199	SLC35B2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLC35B2	VGNC	VGNC:46365
Rattus norvegicus	SLC35B2	RGD	RGD:1565318
Felis catus	SLC35B2	VGNC	VGNC:102518
Mus musculus	SLC35B2	MGD	MGI:1921086
Bos taurus	SLC35B2	VGNC	VGNC:34824
Macaca mulatta	SLC35B2	VGNC	VGNC:83469

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