2. Gene
  3. SLC35B2 - solute carrier family 35 member B2 Gene

SLC35B2 - solute carrier family 35 member B2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SLL; PAPST1; UGTrel4

Gene ID: 347734 | Gene type: protein coding

About SLC35B2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,254,101-44,257,890 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 17.2), thyroid (RPKM 15.1) and 25 other tissues.

Summary

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

SLC35B2 Products(9)

mRNA Protein Name
NM_001286509.2 NP_001273438.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286510.2 NP_001273439.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286511.2 NP_001273440.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286512.2 NP_001273441.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286513.2 NP_001273442.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform d precursor
NM_001286517.2 NP_001273446.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e
NM_001286519.2 NP_001273448.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_001286520.2 NP_001273449.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_178148.4 NP_835361.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
IDA: Inferred from direct assay
12716889 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in 3'-phosphoadenosine 5'-phosphosulfate transport IDA
IDA: Inferred from direct assay
12716889 GOA
involved in chondroitin sulfate biosynthetic process IMP
IMP: Inferred from mutant phenotype
35325049 GOA
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
12716889 GOA
located in Golgi membrane IDA
IDA: Inferred from direct assay
12716889 GOA
located in membrane IDA
IDA: Inferred from direct assay
12716889 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC35B2 Protein Structure

UAA

UAA: UAA transporter family (112 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

adenosine 3'-phospho 5'-phosphosulfate transporter 1

3'-phosphoadenosine 5'-phosphosulfate transporter

SLC35B2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC35B2 Q8TB61 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
Intra
SLC35B2 Q8TB61 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
SLC35B2 Q8TB61 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 RNF170 Homo sapiens Q96K19-5
Validated Y2H
32296183
Intra
SLC35B2 Q8TB61 RNF170 Homo sapiens Q96K19-5
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 RNF170 Homo sapiens Q96K19-5
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 CLDN15 Homo sapiens Q96FX9
Validated Y2H
32296183
Intra
SLC35B2 Q8TB61 CLDN15 Homo sapiens Q96FX9
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 CLDN15 Homo sapiens Q96FX9
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 CD69 Homo sapiens Q07108
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 CD69 Homo sapiens Q07108
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SLC35B2 Q8TB61 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra
SLC35B2 Q8TB61 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
SLC35B2 Q8TB61 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
SLC35B2 Q8TB61 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Primary Bone Dysplasia With Multiple Joint Dislocations

Primary Osteodysplasia With Multiple Joint Dislocations

Primary Skeletal Dysplasia With Multiple Joint Dislocations
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13199 SLC35B2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SLC35B2 VGNC VGNC:46365
Rattus norvegicus SLC35B2 RGD RGD:1565318
Felis catus SLC35B2 VGNC VGNC:102518
Mus musculus SLC35B2 MGD MGI:1921086
Bos taurus SLC35B2 VGNC VGNC:34824
Macaca mulatta SLC35B2 VGNC VGNC:83469