SELENOV - selenoprotein V Gene

Homo sapiens

Also known as SELV

Gene ID: 348303 | Gene type: protein coding

About SELENOV

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,515,113-39,520,686 (from NCBI)

This gene has 3 transcripts (splice variants), 41 orthologues and 2 paralogues. Restricted expression toward testis (RPKM 2.7).

Summary

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is specifically expressed in the testis. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Apr 2017]

SELENOV Products(2)

mRNA	Protein	Name
NM_001350809.1	NP_001337738.1	selenoprotein V isoform 2
NM_182704.2	NP_874363.1	selenoprotein V isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOV Protein Structure

Rdx

0
100
200
300
346 a.a.

Protein Preferred Names

Protein Names

selenoprotein V

SELENOV Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SELENOV	P59797	PRR20C	Homo sapiens	P86479	Validated Y2H	25416956
Intra	SELENOV	P59797	PRR20C	Homo sapiens	P86479	Y2H Prey Pooling	25416956
Intra	SELENOV	P59797	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
Intra	SELENOV	P59797	ZMIZ2	Homo sapiens	Q8NF64-2	Validated Y2H	25416956
Intra	SELENOV	P59797	QRICH1	Homo sapiens	Q2TAL8	Validated Y2H	32296183
Intra	SELENOV	P59797	GOLGA2	Homo sapiens	Q08379	Validated Y2H	25416956
Intra	SELENOV	P59797	PIN1	Homo sapiens	Q13526	Validated Y2H	32296183
Intra	SELENOV	P59797	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183
Intra	SELENOV	P59797	EFHC1	Homo sapiens	Q5JVL4	Validated Y2H	32296183
Intra	SELENOV	P59797	APPBP2	Homo sapiens	Q92624	Y2H Prey Pooling	25416956
Intra	SELENOV	P59797	ZMYND19	Homo sapiens	Q96E35	Y2H Prey Pooling	25416956
Intra	SELENOV	P59797	ZMYND19	Homo sapiens	Q96E35	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nuclear Senile Cataract

Senile Nuclear Cataract

Senile Nuclear Sclerosis

Keshan Disease

Caused By Deficiency Of Selenium In The Diet

Enlarged Heart And Poor Heart Function

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12644	SELENOV Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SELENOV	MGD	MGI:3608324
Bos taurus	SELENOV	VGNC	VGNC:52246
Rattus norvegicus	SELENOV	RGD	RGD:1562943

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