RILPL1 - Rab interacting lysosomal protein like 1 Gene

Homo sapiens

Also known as RLP1; OPDM4; GOSPEL

Gene ID: 353116 | Gene type: protein coding

About RILPL1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,470,054-123,533,719 (from NCBI)

This gene has 5 transcripts (splice variants), 258 orthologues, 4 paralogues and is associated with 1 phenotype. Broad expression in heart (RPKM 11.5), thyroid (RPKM 5.2) and 23 other tissues.

Summary

Predicted to enable protein dimerization activity. Predicted to be involved in several processes, including cilium assembly; epithelial cell morphogenesis; and protein transport from ciliary membrane to plasma membrane. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RILPL1 Products(4)

mRNA	Protein	Name
NM_001319243.2	NP_001306172.1	RILP-like protein 1 isoform 2
NM_001319244.2	NP_001306173.1	RILP-like protein 1 isoform 3
NM_001319302.2	NP_001306231.1	RILP-like protein 1 isoform 3
NM_178314.5	NP_847884.2	RILP-like protein 1 isoform 1

RILPL1 Protein Structure

Jnk-SapK_ap_N

RILP

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

RILP-like protein 1

GAPDH competitor of SIAH protein enhances life

RILPL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RILPL1	Q5EBL4	RAB8A	Homo sapiens	P61006	Anti Tag CoIP	29125462

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oculopharyngodistal Myopathy 4

OPDM4

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11974	RILPL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RILPL1	VGNC	VGNC:76842
Felis catus	RILPL1	VGNC	VGNC:64628
Mus musculus	RILPL1	MGD	MGI:1922945
Rattus norvegicus	RILPL1	RGD	RGD:1307973
Bos taurus	RILPL1	VGNC	VGNC:33967
Canis familiaris	RILPL1	VGNC	VGNC:45577

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