FOXK2 - forkhead box K2 Gene

Homo sapiens

Also known as ILF; ILF1; ILF-1; nGTBP

Gene ID: 3607 | Gene type: protein coding

About FOXK2

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,519,732-82,604,602 (from NCBI)

This gene has 12 transcripts (splice variants), 273 orthologues and 42 paralogues. Ubiquitous expression in testis (RPKM 11.2), brain (RPKM 8.3) and 25 other tissues.

Summary

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

FOXK2 Products(1)

mRNA	Protein	Name
NM_004514.4	NP_004505.2	forkhead box protein K2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9065434	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9065434	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	16624804	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1339390	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	22083952	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20810654	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22083952	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9065434	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20810654	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXK2 Protein Structure

FHA

Forkhead

0
200
400
600
660 a.a.

Protein Preferred Names

Protein Names

forkhead box protein K2

FOXK1

FOXK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FOXK2	Q01167	IRF2	Homo sapiens	P14316	Anti Tag CoIP	21903422
Intra	FOXK2	Q01167	IRF2	Homo sapiens	P14316	TAP	25609649
Intra	FOXK2	Q01167	MAX	Homo sapiens	P61244	TAP	25609649

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05060	FOXK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOXK2	MGD	MGI:1916087
Bos taurus	FOXK2	VGNC	VGNC:55831
Felis catus	FOXK2	VGNC	VGNC:67789
Macaca mulatta	FOXK2	VGNC	VGNC:72711
Canis familiaris	FOXK2	VGNC	VGNC:84864
Rattus norvegicus	FOXK2	RGD	RGD:1305408

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