Cnih2 - cornichon family AMPA receptor auxiliary protein 2 Gene

Rattus norvegicus

Also known as Cnih3; CNIH-2; RGD1304930

Gene ID: 361705 | Gene type: protein coding

About Cnih2

Summary

Involved in negative regulation of anterograde synaptic vesicle transport; negative regulation of receptor localization to synapse; and regulation of neurotransmitter receptor activity. Acts upstream of or within glutamatergic synaptic transmission; localization within membrane; and regulation of membrane potential. Located in dendritic shaft and postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in glutamatergic synapse. Is integral component of postsynaptic density membrane. Orthologous to human CNIH2 (cornichon family AMPA Receptor auxiliary protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Cnih2 Products(1)

mRNA	Protein	Name
NM_001025132.1	NP_001020303.1	protein cornichon homolog 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20805473	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within localization within membrane	IDA IDA: Inferred from direct assay	19265014	RGD
involved in negative regulation of anterograde synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	24094107	RGD
involved in negative regulation of receptor localization to synapse	IMP IMP: Inferred from mutant phenotype	24094107	RGD
involved in regulation of AMPA receptor activity	IDA IDA: Inferred from direct assay	19265014	RGD
involved in regulation of AMPA receptor activity	IMP IMP: Inferred from mutant phenotype	24094107	RGD
involved in regulation of NMDA receptor activity	IMP IMP: Inferred from mutant phenotype	24094107	RGD
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	19265014	RGD
acts upstream of or within synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	19265014	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	19265014	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	19265014	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21172611	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24853943	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	21172611	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	19265014	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein cornichon homolog 2

cornichon homolog 2	cornichon homolog 3
cornichon-like protein

Cnih2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cnih2	Q5BJU5	Gria1	Rattus norvegicus	P19490	Anti Bait CoIP	20805473

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02885	CNIH2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cnih2	NCBI	NCBI:254263

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