2. Gene
  3. Carm1 - coactivator-associated arginine methyltransferase 1 Gene

Carm1 - coactivator-associated arginine methyltransferase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Prmt4

Gene ID: 363026 | Gene type: protein coding

About Carm1

Primary_assembly 8: 20,097,254-20,147,689 forward strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 218 orthologues, 10 paralogues and is associated with 8 phenotypes. Biased expression in Muscle (RPKM 111.1), Heart (RPKM 11.5) and 9 other tissues.

Summary

Predicted to enable several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including negative regulation of dendrite development; regulation of mRNA binding activity; and response to cAMP. Located in cytoplasm and nucleus. Biomarker of asthma; hepatocellular adenoma; and hepatocellular carcinoma. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Carm1 Products(2)

mRNA Protein Name
NM_001034088.3 NP_001029260.1 histone-arginine methyltransferase CARM1 isoform b
NM_001030041.4 NP_001025212.1 histone-arginine methyltransferase CARM1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16330542 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
22736542 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16508003 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
16330542 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Carm1 Protein Structure

CARM1

CARM1: pfam11531 (34 - 138)

SmtA

SmtA: COG0500 (184 - 394)

AdoMet_MTases

AdoMet_MTases: cd02440 (188 - 283)

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  • 500
  • 608 a.a.
Protein Preferred Names Protein Names

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

Related Agents

Pre-clinical Phase
Bioactive Molecules (26)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114965 TP-064 Inhibitor 99.61% Unkown
HY-111109 EZM 2302 Inhibitor 99.59% Unkown
HY-100565 SGC2085 Inhibitor 99.46% Unkown
HY-110137 Furamidine dihydrochloride Inhibitor ≥99.0% Unkown
HY-12759 CARM1-IN-1 Inhibitor ≥95.0% Unkown
HY-15214 CARM1-IN-3 Inhibitor 98.90% Unkown
HY-15214A CARM1-IN-3 dihydrochloride Inhibitor 98.77% Unkown
HY-156152A CARM1 degrader-1 hydrochloride Degrader / Unkown
HY-12759A CARM1-IN-1 hydrochloride Inhibitor 95.13% Unkown
HY-157388 CARM1/HDAC2-IN-1 Inhibitor 95.17% Unkown
HY-100855 DC_C66 Inhibitor / Unkown
HY-100565A SGC2085 hydrochloride Inhibitor / Unkown
HY-110137A Furamidine Inhibitor / Unkown
HY-136809 PRMT6-IN-2 Inhibitor / Unkown
HY-156152 CARM1 degrader-1 Inhibitor / Unkown
HY-156153 CARM1 degrader-2 Inhibitor / Unkown
HY-158157 ZL-28-6 Inhibitor / Unkown
HY-158158 CARM1-IN-5 Inhibitor / Unkown
HY-161334 CARM1-IN-4 / Unkown
HY-163561 CARM1-IN-6 Inhibitor / Unkown
HY-RS01926 CARM1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01927 Carm1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01928 Carm1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-114206 SKI-73 / Unkown
HY-117927 EPZ0025654 Inhibitor / Unkown
HY-W013500 (1-Nitroethene-1,2-diyl)dibenzene Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Carm1 NCBI NCBI:10498