CARM1 - coactivator associated arginine methyltransferase 1 Gene

Homo sapiens

Also known as PRMT4

Gene ID: 10498 | Gene type: protein coding

About CARM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,871,553-10,923,075 (from NCBI)

This gene has 10 transcripts (splice variants), 218 orthologues and 7 paralogues. Ubiquitous expression in testis (RPKM 20.7), placenta (RPKM 17.2) and 25 other tissues.

Summary

This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded Enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The Enzyme acts specifically on histones and Other chromatin-associated proteins and is involved in regulation of gene expression. The Enzyme may act in association with Other proteins or within multi-protein complexes and may play a role in cell type-specific functions and cell lineage specification. A related pseudogene is located on chromosome 9. [provided by RefSeq, Aug 2013]

CARM1 Products(5)

mRNA	Protein	Name
NM_199141.2	NP_954592.1	histone-arginine methyltransferase CARM1 isoform 1
XM_047438058.1	XP_047294014.1	histone-arginine methyltransferase CARM1 isoform X1
NM_001370088.1	NP_001357017.1	histone-arginine methyltransferase CARM1 isoform 2
NM_001370089.1	NP_001357018.1	histone-arginine methyltransferase CARM1 isoform 3
XM_011527638.3	XP_011525940.1	histone-arginine methyltransferase CARM1 isoform X2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15471871	GOA
enables histone H3R17 methyltransferase activity	IDA IDA: Inferred from direct assay	15471871	GOA
enables histone H3R2 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	17898714	GOA
enables histone arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	23980157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16938873	GOA
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	18495660	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	15471871	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of epithelial cell apoptotic process	IDA IDA: Inferred from direct assay	34480022	GOA
involved in positive regulation of transcription by RNA polymerase I	IDA IDA: Inferred from direct assay	15471871	GOA
involved in replication fork reversal	IDA IDA: Inferred from direct assay	33412112	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15221992	GOA
is active in nuclear replication fork	IDA IDA: Inferred from direct assay	33412112	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15221992	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARM1 Protein Structure

CARM1

PRMT5

0
100
200
300
400
500
608 a.a.

Protein Preferred Names

Protein Names

histone-arginine methyltransferase CARM1

protein arginine N-methyltransferase 4

CARM1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	CARM1	Q86X55	a0a1u8qn96_yerpe	Yersinia pestis	A0A1U8QN96	Y2H Array	21911467
Intra	CARM1	Q86X55	SMARCC1	Homo sapiens	Q92922	Anti Tag CoIP	24434208
Intra	CARM1	Q86X55	NUDT21	Homo sapiens	O43809	Anti Tag CoIP	23455924
Intra	CARM1	Q86X55	DNAJA3	Homo sapiens	Q96EY1	Y2H	23455924
Intra	CARM1	Q86X55	NCOA3	Homo sapiens	Q9Y6Q9	Anti Bait CoIP	16938873
Intra	CARM1	Q86X55	QKI	Homo sapiens	Q96PU8	Y2H	23455924
Intra	CARM1	Q86X55	CEBPB	Homo sapiens	P17676	Anti Bait CoIP	20111005
Intra	CARM1	Q86X55	CEBPB	Homo sapiens	P17676	Anti Tag CoIP	20111005
Cross	CARM1	Q86X55	CEBPB	Gallus gallus	Q05826	Anti Tag CoIP	20111005

Cross: Cross-species interaction Intra: Intraspecies interaction

CARM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80583	CARM1 Antibody (YA812)	WB, IP	Human, Mouse

Related Diseases

Diseases

Alias

Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations

Severe Congenital Encephalopathy Due To Mecp2 Mutation	Severe Neonatal-Onset Encephalopathy With Microcephaly
Encephalopathy, Neonatal Severe	Neonatal Severe Encephalopathy Due To Mecp2 Mutations
Mecp2-Related Severe Neonatal Encephalopathy	Methyl-Cytosine Phosphate Guanine Binding Protein 2 Related Severe Neonatal Encephalopathy
Severe Neonatal Encephalopathy Due To Mecp2 Mutations	ENS-MECP2
Encephalopathy, Neonatal, Severe

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114965	TP-064	Inhibitor	99.61%	Unkown
HY-111109	EZM 2302	Inhibitor	99.59%	Unkown
HY-100565	SGC2085	Inhibitor	99.46%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-12759	CARM1-IN-1	Inhibitor	≥95.0%	Unkown
HY-15214	CARM1-IN-3	Inhibitor	98.90%	Unkown
HY-15214A	CARM1-IN-3 dihydrochloride	Inhibitor	98.77%	Unkown
HY-156152A	CARM1 degrader-1 hydrochloride	Degrader	/	Unkown
HY-12759A	CARM1-IN-1 hydrochloride	Inhibitor	95.13%	Unkown
HY-157388	CARM1/HDAC2-IN-1	Inhibitor	95.17%	Unkown
HY-100855	DC_C66	Inhibitor	/	Unkown
HY-100565A	SGC2085 hydrochloride	Inhibitor	/	Unkown
HY-110137A	Furamidine	Inhibitor	/	Unkown
HY-136809	PRMT6-IN-2	Inhibitor	/	Unkown
HY-156152	CARM1 degrader-1	Inhibitor	/	Unkown
HY-156153	CARM1 degrader-2	Inhibitor	/	Unkown
HY-158157	ZL-28-6	Inhibitor	/	Unkown
HY-158158	CARM1-IN-5	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4		/	Unkown
HY-163561	CARM1-IN-6	Inhibitor	/	Unkown
HY-RS01926	CARM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01927	Carm1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01928	Carm1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-114206	SKI-73		/	Unkown
HY-117927	EPZ0025654	Inhibitor	/	Unkown
HY-W013500	(1-Nitroethene-1,2-diyl)dibenzene	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CARM1	VGNC	VGNC:60369
Bos taurus	CARM1	VGNC	VGNC:26767
Macaca mulatta	CARM1	VGNC	VGNC:70612
Canis familiaris	CARM1	VGNC	VGNC:38721
Mus musculus	CARM1	MGD	MGI:1913208
Rattus norvegicus	CARM1	RGD	RGD:1305879
Others	CARM1	NCBI

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