ITGA3 - integrin subunit alpha 3 Gene

Homo sapiens

Also known as JEB7; VL3A; CD49C; FRP-2; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3

Gene ID: 3675 | Gene type: protein coding

About ITGA3

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,056,110-50,090,481 (from NCBI)

This gene has 16 transcripts (splice variants), 286 orthologues, 17 paralogues and is associated with 3 phenotypes. Broad expression in lung (RPKM 53.0), thyroid (RPKM 21.5) and 19 other tissues.

Summary

The gene encodes a member of the Integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function as cell surface adhesion molecules. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 3 subunit. This subunit joins with a beta 1 subunit to form an Integrin that interacts with extracellular matrix proteins including members of the laminin family. Expression of this gene may be correlated with breast Cancer metastasis. [provided by RefSeq, Oct 2015]

ITGA3 Products(1)

mRNA	Protein	Name
NM_002204.4	NP_002195.1	integrin alpha-3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	10455171	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1911778	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	10455171	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lung development	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in mesodermal cell differentiation	IEP IEP: Inferred from expression pattern	23154389	GOA
involved in nephron development	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in positive regulation of protein localization to plasma membrane	IDA IDA: Inferred from direct assay	10455171	GOA
involved in regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in renal filtration	IMP IMP: Inferred from mutant phenotype	24621570	GOA
involved in skin development	IMP IMP: Inferred from mutant phenotype	24621570	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell periphery	IDA IDA: Inferred from direct assay	24220332	GOA
located in cell surface	IDA IDA: Inferred from direct assay	19933311	GOA
located in filopodium membrane	IDA IDA: Inferred from direct assay	10455171	GOA
part of integrin alpha3-beta1 complex	IDA IDA: Inferred from direct assay	25063885	GOA
part of integrin alpha3-beta1 complex	IMP IMP: Inferred from mutant phenotype	24220332	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	21310825	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGA3 Protein Structure

VCBS

Integrin_alpha2

0
200
400
600
800
1051 a.a.

Protein Preferred Names

Protein Names

integrin alpha-3

CD49 antigen-like family member C

ITGA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ITGA3	P26006	CD151	Homo sapiens	P48509	Confocal	14557253
Intra	ITGA3	P26006	LGALS1	Homo sapiens	P09382	Crosslink	30021884

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epidermolysis Bullosa, Junctional 7, With Interstitial Lung Disease And Nephrotic Syndrome

JEB7	Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
Ilneb	Congenital Nephrotic Syndrome - Interstitial Lung Disease - Epidermolysis Bullosa Syndrome
Interstitial Lung Disease-Nephrotic Syndrome-Epidermolysis Bullosa Syndrome	Ilneb Syndrome
Jeb With Interstitial Lung Disease And Nephrotic Syndrome	Junctional Epidermolysis Bullosa With Interstitial Lung Disease And Nephrotic Syndrome
Lung Disease, Interstitial, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital

Mucormycosis

Zygomycosis	Disseminated Mucormycosis
Absidia Infection	Absidia Mucoromycosis
Cunninghamella Infection	Cunninghamella Mucoromycosis
Infection By Absidia Spp	Infection By Rhizopus Spp
Mucor Infection	Mucor Mucoromycosis
Infection By Mucor Spp	Rhizopus Infection
Rhizopus Mucoromycosis	Infection By Cunninghamella Spp
Phycomycosis Nos

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Interstitial Lung Disease

Ild	Lung Diseases, Interstitial
Lung Diseases Interstitial	Interstitial Lung Diseases

Epidermolysis Bullosa

Acantholysis Bullosa

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Fraser Syndrome 1

Fraser Syndrome	Cryptophthalmos With Other Malformations
Cryptophthalmos Syndrome	FRASRS1
Cryptophthalmos-Syndactyly Syndrome	Fraser-Francois Syndrome
Cyclopism	Meyer-Schwickerath'S Syndrome
Ulrich-Feichtiger Syndrome	Cryptophthalmos Syndactyly Syndrome
Fraser'S Syndrome	Meyer-Schwickerath Syndrome
Ullrich-Feichtiger Syndrome

Hydrocele

Testicular Hydrocele

Villous Adenocarcinoma

Fibrosarcoma

Neoplasms, Fibrous Tissue	Fibrocytic Tumor
Fibrosarcoma Of Soft Tissue	Fibrous Tissue Neoplasm

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional	Jeb
Epidermolysis Bullosa Atrophicans	Congenital Junctional Epidermolysis Bullosa
Epidermolysis Bullosa Junctional	Junctional Eb - [Epidermolysis Bullosa]
Jeb - [Junctional Epidermolysis Bullosa]	Lucidolytic Epidermolysis Bullosa

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Galloway-Mowat Syndrome

Galloway Mowat Syndrome	Galloway Syndrome
Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type	Microcephaly Nephrosis Syndrome
Microcephaly, Hiatal Hernia, And Nephrotic Syndrome	Nephrosis Neuronal Dysmigration Syndrome
Microcephaly-Hiatus Hernia-Nephrotic Syndrome	Nephrosis-Neuronal Dysmigration Syndrome

Alport Syndrome

Hereditary Nephritis	Alport Syndrome, X-Linked
Hemorrhagic Hereditary Nephritis	Congenital Hereditary Hematuria
Hemorrhagic Familial Nephritis	Familial Nephritis
Thin Basement Membrane Disease	Thin Basement Membrane Nephropathy
Hematuria-Nephropathy-Deafness Syndrome	Hematuric Hereditary Nephritis
Hereditary Familial Congenital Hemorrhagic Nephritis	Hereditary Hematuria Syndrome
Hereditary Interstitial Pyelonephritis	Alport Deafness-Nephropathy
Alport Hearing Loss-Nephropathy	Alports Syndrome
Nephritis, Hereditary

Basal Cell Carcinoma

Basal Cell Cancer	Basal Cell Neoplasm
Basal Cell Carcinoma Of Skin	Malignant Basal Cell Tumor
Basal Cell Tumor	Epithelioma Basal Cell
Malignant Basal Cell Neoplasm	Rodent Ulcer
Carcinoma Basal Cell	Neoplasms, Basal Cell
Basal Cell Carcinomas	Experimental Organism Basal Cell Carcinoma
Nodulo-Ulcerative Basal Cell Carcinoma	Basalioma
Basal Cell Epithelioma Of Skin	Bcc - [Basal Cell Carcinoma] Of Skin
Rodent Ulcer Of Skin	Rodent Ulcer Of Unspecified Site
Basal Cell Epithelioma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06950	ITGA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ITGA3	MGD	MGI:96602
Felis catus	ITGA3	VGNC	VGNC:67841
Bos taurus	ITGA3	VGNC	VGNC:30315
Canis familiaris	ITGA3	VGNC	VGNC:42125
Rattus norvegicus	ITGA3	RGD	RGD:1310333
Macaca mulatta	ITGA3	VGNC	VGNC:73777

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