2. Gene
  3. CD151 - CD151 molecule (Raph blood group) Gene

CD151 - CD151 molecule (Raph blood group) Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EBS7; GP27; MER2; RAPH; SFA1; PETA-3; TSPAN24

Gene ID: 977 | Gene type: protein coding

About CD151

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:832,952-838,831 (from NCBI)

This gene has 23 transcripts (splice variants), 262 orthologues, 32 paralogues and is associated with 4 phenotypes. Ubiquitous expression in fat (RPKM 188.8), lung (RPKM 142.9) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and Other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate Integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of Cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

CD151 Products(4)

mRNA Protein Name
NM_001039490.2 NP_001034579.1 CD151 antigen
NM_004357.5 NP_004348.2 CD151 antigen
NM_139029.2 NP_620598.1 CD151 antigen
NM_139030.4 NP_620599.1 CD151 antigen
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables integrin binding IDA
IDA: Inferred from direct assay
17716972 GOA
enables integrin binding IPI
IPI: Inferred from physical interaction
24220332 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10811835 GOA
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of cell migration IDA
IDA: Inferred from direct assay
17716972 GOA
acts upstream of or within positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17716972 GOA
acts upstream of or within positive regulation of endocytosis IDA
IDA: Inferred from direct assay
17716972 GOA
acts upstream of or within positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
17716972 GOA
acts upstream of or within wound healing, spreading of cells IDA
IDA: Inferred from direct assay
17716972 GOA
acts upstream of or within wound healing, spreading of cells IMP
IMP: Inferred from mutant phenotype
17716972 GOA
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
23302890 GOA
located in cell surface IDA
IDA: Inferred from direct assay
17716972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD151 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (15 - 247)

  • 0
  • 100
  • 200
  • 253 a.a.
Protein Preferred Names Protein Names

CD151 antigen

CD151 antigen (Raph blood group)

CD151 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CD151 P48509 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
CD151 P48509 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CD151 P48509 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CD151 P48509 TSPAN18 Homo sapiens Q8WUV1
Y2H Prey Pooling
32296183
Intra
CD151 P48509 TSPAN18 Homo sapiens Q8WUV1
Validated Y2H
32296183
Intra
CD151 P48509 TSPAN18 Homo sapiens Q8WUV1
Y2H Array
32296183
Intra
CD151 P48509 ITGA6 Homo sapiens P23229
Confocal
10811835
Intra
CD151 P48509 ITGA6 Homo sapiens P23229
Anti Bait CoIP
10811835
Intra
CD151 P48509 ITGA6 Homo sapiens P23229
Anti Tag CoIP
33961781
Intra
CD151 P48509 ITGA6 Homo sapiens P23229
Anti Tag CoIP
35271311
Intra
CD151 P48509 ITGA3 Homo sapiens P26006
Anti Bait CoIP
10811835
Intra
CD151 P48509 ITGA3 Homo sapiens P26006
Anti Tag CoIP
33961781
Intra
CD151 P48509 ITGA3 Homo sapiens P26006
Confocal
10811835
Intra
CD151 P48509 ITGA3 Homo sapiens P26006
Anti Bait CoIP
14557253
Intra
CD151 P48509 ITGA3 Homo sapiens P26006
Anti Tag CoIP
14557253
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Validated Y2H
25910212
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Y2H Bait-Prey Pool
25910212
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Validated Y2H
25416956
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Validated Y2H
32296183
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Y2H Prey Pooling
25416956
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Y2H Array
32296183
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Y2H Array
25910212
Intra
CD151 P48509 GRAMD1C Homo sapiens Q8IYS0
Y2H Prey Pooling
32296183
Intra
CD151 P48509 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
CD151 P48509 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra
CD151 P48509 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
CD151 P48509 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra
CD151 P48509 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Intra
CD151 P48509 ITGB4 Homo sapiens P16144
Confocal
10811835
Intra
CD151 P48509 ITGB4 Homo sapiens P16144
Anti Tag CoIP
33961781
Intra
CD151 P48509 ITGB4 Homo sapiens P16144
Anti Bait CoIP
10811835
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epidermolysis Bullosa Simplex 7, With Nephropathy And Deafness

Nephropathy With Pretibial Epidermolysis Bullosa And Deafness

EBS7

Nephrotic Syndrome-Epidermolysis Bullosa-Sensorineural Deafness Syndrome

Ebs With Nephropathy

Epidermolysis Bullosa Simplex With Nephropathy

Nephrotic Syndrome-Hearing Loss-Epidermolysis Bullosa Syndrome

Npebd
Raph Blood Group System

Mer2 Blood Cell Antigen Expression

Mer2

Blood Group System, Raph
Epidermolysis Bullosa Simplex

Ebs

Epidermolysis Bullosa Intraepidermic

Epidermolytic Epidermolysis Bullosa
Thalassemia Minor
Epidermolysis Bullosa

Acantholysis Bullosa

Eb
Kindler Syndrome

Poikiloderma Of Kindler

Bullous Acrokeratotic Poikiloderma Of Kindler And Weary

Congenital Bullous Poikiloderma

KNDLRS

Poikiloderma, Hereditary Acrokeratotic

Poikiloderma, Congenital, With Bullae, Weary Type

Kindler'S Syndrome

Poikiloderma Congenital With Bullae Weary Type

Hereditary Acrokeratotic Poikiloderma Of Kindler-Weary

Hereditary Acrokeratotic Poikiloderma

Weary Syndrome

Poikiloderma Hereditary Acrokeratotic

Potassium Deficiency
Retinitis Pigmentosa 44

RP44

Retinitis Pigmentosa, Type 44
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Transient Bullous Dermolysis Of The Newborn

TBDN

Transient Bullous Of The Newborn

Epidermolysis Bullosa Dystrophica, Neonatal Form

Dystrophic Epidermolysis Bullosa, Neonatal

Deb, Bullous Dermolysis Of The Newborn

Deb-Bdn

Epidermolysis Bullosa Dystrophica, Dominant Neonatal Form

Self-Improving Dystrophic Epidermolysis Bullosa

Self-Improving Deb

Epidermolysis Bullosa Dystrophica Dominant Neonatal Type
Junctional Epidermolysis Bullosa

Epidermolysis Bullosa, Junctional

Jeb

Epidermolysis Bullosa Atrophicans

Congenital Junctional Epidermolysis Bullosa

Epidermolysis Bullosa Junctional

Junctional Eb - [Epidermolysis Bullosa]

Jeb - [Junctional Epidermolysis Bullosa]

Lucidolytic Epidermolysis Bullosa
Epidermolysis Bullosa, Junctional 5b, With Pyloric Atresia

Junctional Epidermolysis Bullosa With Pyloric Atresia

Carmi Syndrome

Epidermolysis Bullosa, Junctional, With Pyloric Atresia

Jeb-Pa

JEB5B

Epidermolysis Bullosa Junctionalis With Pyloric Atresia

Aplasia Cutis Congenita With Gastrointestinal Atresia

Epidermolysis Bullosa, Junctional, With Pyloric Atresia And Aplasia Cutis Congenita

Eb-Pa-Acc

Junctional Epidermolysis Bullosa-Pyloric Atresia Syndrome

Jeb With Pyloric Atresia

Epidermolysis Bullosa Letalis, With Pyloric Atresia

Pa-Jeb

Epidermolysis Bullosa With Pyloric Atresia
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Tibial Adamantinoma

Tibial Adamantinoma Morphology
Alport Syndrome

Hereditary Nephritis

Alport Syndrome, X-Linked

Hemorrhagic Hereditary Nephritis

Congenital Hereditary Hematuria

Hemorrhagic Familial Nephritis

Familial Nephritis

Thin Basement Membrane Disease

Thin Basement Membrane Nephropathy

Hematuria-Nephropathy-Deafness Syndrome

Hematuric Hereditary Nephritis

Hereditary Familial Congenital Hemorrhagic Nephritis

Hereditary Hematuria Syndrome

Hereditary Interstitial Pyelonephritis

Alport Deafness-Nephropathy

Alport Hearing Loss-Nephropathy

Alports Syndrome

Nephritis, Hereditary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02190 CD151 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CD151 MGD MGI:1096360
Macaca mulatta CD151 VGNC VGNC:100903
Canis familiaris CD151 VGNC VGNC:51858
Felis catus CD151 VGNC VGNC:81915
Bos taurus CD151 VGNC VGNC:53655
Rattus norvegicus CD151 RGD RGD:621290
Others CD151 NCBI