ITGB7 - integrin subunit beta 7 Gene

Homo sapiens

Gene ID: 3695 | Gene type: protein coding

About ITGB7

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,191,323-53,207,251 (from NCBI)

This gene has 14 transcripts (splice variants), 154 orthologues and 8 paralogues. Broad expression in spleen (RPKM 15.4), lymph node (RPKM 15.4) and 19 other tissues.

Summary

This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

ITGB7 Products(18)

mRNA	Protein	Name
NM_000889.3	NP_000880.1	integrin beta-7 isoform a precursor
NM_001414156.1	NP_001401085.1	integrin beta-7 isoform a precursor
NM_001414157.1	NP_001401086.1	integrin beta-7 isoform a precursor
NM_001414158.1	NP_001401087.1	integrin beta-7 isoform a precursor
NM_001414159.1	NP_001401088.1	integrin beta-7 isoform a precursor
NM_001414160.1	NP_001401089.1	integrin beta-7 isoform a precursor
NM_001414161.1	NP_001401090.1	integrin beta-7 isoform a precursor
NM_001414162.1	NP_001401091.1	integrin beta-7 isoform b precursor
NM_001414163.1	NP_001401092.1	integrin beta-7 isoform b precursor
NM_001414164.1	NP_001401093.1	integrin beta-7 isoform b precursor
NM_001414165.1	NP_001401094.1	integrin beta-7 isoform c precursor
NM_001414166.1	NP_001401095.1	integrin beta-7 isoform c precursor
NM_001414167.1	NP_001401096.1	integrin beta-7 isoform c precursor
NM_001414169.1	NP_001401098.1	integrin beta-7 isoform d precursor
NM_001414170.1	NP_001401099.1	integrin beta-7 isoform d precursor
NM_001414171.1	NP_001401100.1	integrin beta-7 isoform d precursor
NM_001414172.1	NP_001401101.1	integrin beta-7 isoform d precursor
NM_001414173.1	NP_001401102.1	integrin beta-7 isoform e

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IMP IMP: Inferred from mutant phenotype	23986478	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	1542691	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	22232704	GOA
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in cell-matrix adhesion involved in ameboidal cell migration	IMP IMP: Inferred from mutant phenotype	23986478	GOA
involved in heterotypic cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in integrin-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23986478	GOA
involved in leukocyte tethering or rolling	IMP IMP: Inferred from mutant phenotype	18308860	GOA
involved in receptor clustering	IMP IMP: Inferred from mutant phenotype	23986478	GOA
involved in substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	23986478	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18308860	GOA
part of integrin alpha4-beta7 complex	IDA IDA: Inferred from direct assay	18308860	GOA
part of integrin alpha4-beta7 complex	IPI IPI: Inferred from physical interaction	22232704	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB7 Protein Structure

Integrin_beta

Integrin_b_cyt

0
200
400
600
798 a.a.

Protein Preferred Names

Protein Names

integrin beta-7

gut homing receptor beta subunit

ITGB7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ITGB7	P26010	FLNA	Homo sapiens	P21333	Filter Binding	17690686
Intra	ITGB7	P26010	FLNA	Homo sapiens	P21333	Pull Down	17690686
Intra	ITGB7	P26010	ITGA4	Homo sapiens	P13612	Lex-A Dimerization	14681217

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 18

IBD18

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99184	Abrilumab		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06971	ITGB7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ITGB7	RGD	RGD:2929
Bos taurus	ITGB7	VGNC	VGNC:30332
Felis catus	ITGB7	VGNC	VGNC:67856
Canis familiaris	ITGB7	VGNC	VGNC:42142
Macaca mulatta	ITGB7	VGNC	VGNC:73790
Mus musculus	ITGB7	MGD	MGI:96616
Others	ITGB7	NCBI

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