2. Gene
  3. ITGB7 - integrin subunit beta 7 Gene

ITGB7 - integrin subunit beta 7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 3695 | Gene type: protein coding

About ITGB7

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,191,323-53,207,251 (from NCBI)

This gene has 14 transcripts (splice variants), 154 orthologues and 8 paralogues. Broad expression in spleen (RPKM 15.4), lymph node (RPKM 15.4) and 19 other tissues.

Summary

This gene encodes a protein that is a member of the Integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

ITGB7 Products(18)

mRNA Protein Name
NM_000889.3 NP_000880.1 integrin beta-7 isoform a precursor
NM_001414156.1 NP_001401085.1 integrin beta-7 isoform a precursor
NM_001414157.1 NP_001401086.1 integrin beta-7 isoform a precursor
NM_001414158.1 NP_001401087.1 integrin beta-7 isoform a precursor
NM_001414159.1 NP_001401088.1 integrin beta-7 isoform a precursor
NM_001414160.1 NP_001401089.1 integrin beta-7 isoform a precursor
NM_001414161.1 NP_001401090.1 integrin beta-7 isoform a precursor
NM_001414162.1 NP_001401091.1 integrin beta-7 isoform b precursor
NM_001414163.1 NP_001401092.1 integrin beta-7 isoform b precursor
NM_001414164.1 NP_001401093.1 integrin beta-7 isoform b precursor
NM_001414165.1 NP_001401094.1 integrin beta-7 isoform c precursor
NM_001414166.1 NP_001401095.1 integrin beta-7 isoform c precursor
NM_001414167.1 NP_001401096.1 integrin beta-7 isoform c precursor
NM_001414169.1 NP_001401098.1 integrin beta-7 isoform d precursor
NM_001414170.1 NP_001401099.1 integrin beta-7 isoform d precursor
NM_001414171.1 NP_001401100.1 integrin beta-7 isoform d precursor
NM_001414172.1 NP_001401101.1 integrin beta-7 isoform d precursor
NM_001414173.1 NP_001401102.1 integrin beta-7 isoform e
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cell adhesion molecule binding IMP
IMP: Inferred from mutant phenotype
23986478 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1542691 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell-matrix adhesion IDA
IDA: Inferred from direct assay
22232704 GOA
involved in cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
18308860 GOA
involved in cell-matrix adhesion involved in ameboidal cell migration IMP
IMP: Inferred from mutant phenotype
23986478 GOA
involved in heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18308860 GOA
involved in integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
23986478 GOA
involved in leukocyte tethering or rolling IMP
IMP: Inferred from mutant phenotype
18308860 GOA
involved in receptor clustering IMP
IMP: Inferred from mutant phenotype
23986478 GOA
involved in substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
23986478 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
18308860 GOA
part of integrin alpha4-beta7 complex IDA
IDA: Inferred from direct assay
18308860 GOA
part of integrin alpha4-beta7 complex IPI
IPI: Inferred from physical interaction
22232704 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ITGB7 Protein Structure

Integrin_beta

Integrin_beta: Integrin beta chain VWA domain (50 - 476)

Integrin_b_cyt

Integrin_b_cyt: Integrin beta cytoplasmic domain (747 - 792)

  • 0
  • 200
  • 400
  • 600
  • 798 a.a.
Protein Preferred Names Protein Names

integrin beta-7

gut homing receptor beta subunit

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 18

IBD18
Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia

Arvc

Arvd

Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

Arvc Cardiomyopathy

Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

Arvd/C

Right Ventricular Dysplasia, Arrhythmogenic

Ventricular Dysplasia, Right, Arrhythmogenic

Cardiomyopathy, Ventricular, Right, Arrhythmogenic

Dysplasia, Arrhythmogenic Right Ventricular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99184 Abrilumab / Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06971 ITGB7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ITGB7 RGD RGD:2929
Bos taurus ITGB7 VGNC VGNC:30332
Felis catus ITGB7 VGNC VGNC:67856
Canis familiaris ITGB7 VGNC VGNC:42142
Macaca mulatta ITGB7 VGNC VGNC:73790
Mus musculus ITGB7 MGD MGI:96616
Others ITGB7 NCBI