STT3A - STT3 oligosaccharyltransferase complex catalytic subunit A Gene

Homo sapiens

Also known as TMC; ITM1; STT3-A; CDG1WAD; CDG1WAR

Gene ID: 3703 | Gene type: protein coding

About STT3A

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:125,591,769-125,623,091 (from NCBI)

This gene has 17 transcripts (splice variants), 213 orthologues, 2 paralogues and is associated with 5 phenotypes. Ubiquitous expression in thyroid (RPKM 41.7), endometrium (RPKM 25.2) and 25 other tissues.

Summary

The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

STT3A Products(3)

mRNA	Protein	Name
NM_001278503.2	NP_001265432.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform a
NM_001278504.2	NP_001265433.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform b
NM_152713.5	NP_689926.1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IMP IMP: Inferred from mutant phenotype	19167329	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21903422	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in co-translational protein modification	IMP IMP: Inferred from mutant phenotype	19167329	GOA
involved in protein N-linked glycosylation	IMP IMP: Inferred from mutant phenotype	22467853	GOA
involved in protein N-linked glycosylation via asparagine	IMP IMP: Inferred from mutant phenotype	19167329	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of oligosaccharyltransferase complex	IDA IDA: Inferred from direct assay	22467853	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STT3A Protein Structure

STT3

0
200
400
600
705 a.a.

Protein Preferred Names

Protein Names

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

STT3A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STT3A	P46977	POMK	Homo sapiens	Q9H5K3	Anti Tag CoIP	32707033
Cross	STT3A	P46977	ns7b_sars2	SARS-CoV-2	P0DTD8	Anti Tag CoIP	36217030
Intra	STT3A	P46977	STING1	Homo sapiens	Q86WV6	Anti Tag CoIP	21903422
Intra	STT3A	P46977	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	STT3A	P46977	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	STT3A	P46977	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	STT3A	P46977	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	STT3A	P46977	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	STT3A	P46977	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	STT3A	P46977	RPN1	Homo sapiens	P04843	Anti Tag CoIP	35271311
Intra	STT3A	P46977	RPN1	Homo sapiens	P04843	Crosslink	30021884
Cross	STT3A	P46977	Sarm1	Mus musculus	Q6PDS3	Anti Tag CoIP	21903422
Intra	STT3A	P46977	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	STT3A	P46977	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	STT3A	P46977	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	STT3A	P46977	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	STT3A	P46977	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	STT3A	P46977	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Iw, Autosomal Recessive

Stt3a-Cdg	Cdg-Iw
CDG1W	Congenital Disorder Of Glycosylation Type Iw
CDG1WAR	Cdg Syndrome Type Iw
Congenital Disorder Of Glycosylation Type 1w	Congenital Disorder Of Glycosylation 1w
Cdgiw	Cdg Iw

Congenital Disorder Of Glycosylation, Type Iw, Autosomal Dominant

CDG1WAD

Congenital Disorder Of Glycosylation 1w, Autosomal Dominant

Osteogenesis Imperfecta, Type X

Osteogenesis Imperfecta Type 10	OI10
Osteogenesis Imperfecta Type X	Oi, Type X
Osteogenesis Imperfecta 10	Oi Type X
Oi-X

Granular Cell Carcinoma

Granular Cell Cancer

Granular Cell Adenocarcinoma

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Deafness, Autosomal Dominant 36

DFNA36	Autosomal Dominant Nonsyndromic Deafness 36
Autosomal Dominant Deafness 36	Deafness, Autosomal Dominant, 36
Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 36	Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 36
Deafness, Autosomal Dominant, Type 36

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type

Capillary Malformations, Congenital

Familial Multiple Nevi Flammei	Nevi Flammei, Familial Multiple
CMC	Port-Wine Stain
Capillary Malformations	Cmal
Familial Multiple Port-Wine Stains	Capillary Malformation
Capillary Malformations, Congenital, 1, Somatic, Mosaic	Congenital Capillary Malformations
Port-Wine Stain Familial Multiple	Hereditary Capillary Malformations
Capillary Malformations, Hereditary	Capillary Malformations, Congenital, Type 1, Somatic, Mosaic
Strawberry Nevus Of Skin	Naevus Flammeus

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117383	NGI-1	Inhibitor	99.95%	Unkown
HY-RS13970	STT3A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-169003	STT3A/B-IN-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STT3A	VGNC	VGNC:78263
Mus musculus	STT3A	MGD	MGI:105124
Felis catus	STT3A	VGNC	VGNC:67864
Canis familiaris	STT3A	VGNC	VGNC:46948
Rattus norvegicus	STT3A	RGD	RGD:1565793
Bos taurus	STT3A	VGNC	VGNC:35427

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